The authors report the case of a 47-year-old male, investigating nasopharyngitis and
odynophagia refractory to usual treatment. Imaging investigation showed a large lesion
at the craniocervical junction. The tumor was resected by a targeted endoscopic mononostril
approach, with minimal morbidity to normal nasal structures. Histological diagnosis
showed a classic chordoma. The patient was referred for adjuvant proton-beam therapy
with a favorable outcome. Details of the surgical technique, indications, alternative
approaches, and risks are described.
