Background Nasal polyps by chronic rhinosinusitis are becoming more and more often in adults.
Symptoms as nasal obstruction, rhinorrhea, loss of smell and more are present to the
most of the patients. The ground reason is an eosinophilic inflammation. A biological
treatment, mepolizumab, blocks the inflammatory pathway. In our study we want to show
the efficacy of mepoizumab in patients with chronic rhinosinusitis with nasal polyps
Material and Methods In our private office we have 5 patients (3 women and 2 men) aged 25 to 70 with CRSwNP.
They all had undergone a FESS, 2 of them twice. The Sinonasal Outcome Test Score was
varying from 62 to 87. They all had medical treatments in the past as steroid sprays
and oral cortisone with moderate results without resolving the problem. We used mepolizumab,
100mg subcutaneously every 4 weeks. Follow up was scheduled every 3, 6, 9 and 12 months.
During the follow-up the endoscopy was documented and the patients filled the SNOT
22.
Results All patients as soon as the first follow-up had reduced nasal polyps. SNOT was also
reduced. 2 patients are in follow-up 1,5 year later, still with reduced symptoms.
[1]
Conclusion Mepolizumab improved nasal polyps" size, obstruction and loss of smell with
no side effects. The treatment also reduces the risk of reccurence after operation.
