Keywords
Multiple Sclerosis - Art - Culture - Health - Awareness
INTRODUCTION
Jacqueline du Pré ([Figure 1]) was a transcendent force in classical music, known for her emotionally-charged
interpretations and impeccable technique. However, her career was tragically cut short
by multiple sclerosis (MS), which was diagnosed in 1973. The present paper celebrates
her artistic achievements and highlights how her journey with MS contributed to the
visibility and understanding of the disease.
Figure 1 Picture of Jacqueline Mary du Pré. Source: Chicago Symphony Orchestra Archives (2014).
LIFE AND ART
Born in Oxford, England, Jacqueline was raised in a musically-inclined family. Her
mother was a pianist, and her father had a deep love for classical music. Immersed
in this environment, Jacqueline developed an early affinity for the cello, beginning
lessons at the age of 5 years. Her extraordinary talent led her to the Guildhall School
of Music and Drama, where she studied under William Pleeth. At 15, she won the Queen's
Prize, marking the start of a distinguished career. At 16, she debuted professionally
in London, performing Elgar's “Cello Concerto in E minor” with the London Symphony
Orchestra. This piece became synonymous with her name and cemented her place as a
prodigious talent.[1]
[2]
By 18, Jacqueline was a soloist with the BBC Symphony Orchestra, an extraordinary
feat that reflected her charismatic stage presence. Her renown grew beyond England,
leading to international tours, including a highly-acclaimed United States tour. She
gained a reputation as a deeply-emotional performer, capable of conveying the essence
of complex compositions with remarkable intimacy.[1]
Jacqueline was also an accomplished chamber musician, collaborating with renowned
artists such as Daniel Barenboim, Pinchas Zukerman, and Itzhak Perlman. These collaborations
resulted in highly-regarded recordings that enriched the classical music repertoire.
Among them, her recording of Elgar's “Cello Concerto”, conducted by Sir John Barbirolli,
remains one of the greatest interpretations of the work. Her meteoric rise was defined
by performances that combined flawless technique with deep emotional resonance, securing
her status as one of the most remarkable cellists of the twentieth century.
THE BATTLE AGAINST MULTIPLE SCLEROSIS
THE BATTLE AGAINST MULTIPLE SCLEROSIS
Jacqueline du Pré's brilliant trajectory was tragically altered by MS, a chronic autoimmune
disease that affects the central nervous system. The first signs of the disease appeared
subtly, with a numbness in her fingertips—a devastating premonition for a cellist.
Over time, her physical changes became more pronounced, affecting her ability to perform.
The progression of MS was exacerbated by the side effects of the treatments, particularly
the one with corticosteroids, which caused weight gain and altered her appearance.[3]
Her final performances revealed the full extent of her struggle. While still filled
with emotion, they were marked by visible difficulties in coordination and strength.
The fluidity and control that once defined her playing had become compromised. Yet,
her determination to perform despite the challenges was a testament to her resilience.
Emotionally, she oscillated between denial and acceptance, eventually confiding in
close friends and family.[1]
Jacqueline and her husband, Daniel Barenboim, sought treatment in various countries,
including the Soviet Union and the United States. However, at the time, the available
treatments could do little to halt the disease's progression. Her treatment with corticosteroids
led to visible signs of Cushing's syndrome, including facial swelling and a curved
posture. These changes were evident in interviews and public appearances in the 1970s
and 1980s.[2]
Despite her suffering, Jacqueline du Pré transformed her battle into a powerful legacy
of resilience. Her story highlighted both the fragility of the human body and the
strength of the spirit, inspiring not only musicians but all those who face adversity.
She passed away in 1987. Notably, 6 years after her passing, significant advancements
in MS treatment emerged. In 1993, a clinical trial[4] demonstrated that interferon beta-1b (IFNβ-1b) improved conditions in nearly 30%
of patients with relapsing-remitting MS (RRMS), establishing it as the first effective
therapy to modify the disease course. Subsequent studies[5]
[6] emphasized the importance of early treatment initiation.
CULTURAL IMPACT AND LEGACY
CULTURAL IMPACT AND LEGACY
Beyond her unforgettable performances, Jacqueline du Pré profoundly influenced the
arts and MS awareness. The play Duet for One, by Tom Kempinski ([Figure 2]), is a remarkable artistic expression of this legacy. Inspired by du Pré's battle
with MS, the play provides an emotionally-charged perspective on the challenges faced
by those with chronic illnesses, particularly their impact on identity and relationships.
Figure 2 Booklet of the play Duet for One, by Tom Kempinski.
In Brazil, Duet for One premiered in 1984 at the Ruth Escobar Theater, in the city of São Paulo, starring
actors Othon Bastos and Martha Overbeck. The play not only captivated audiences but
also played a crucial role in raising awareness about MS. Informational pamphlets
on the disease, written by Professor Wilson Luiz Sanvito, were distributed to theatergoers,
making the play a significant moment for MS awareness in Brazil.
An unexpected outcome of the play was the connection formed among audience members
affected by MS. Those using canes or wheelchairs found in each other a sense of solidarity.
This led to the foundation of the Brazilian Multiple Sclerosis Association (Associação
Brasileira de Esclerose Múltipla, ABEM, in Portuguese) by Ana Maria Almeida Amarante
Levy and Dr. Renato Basile.[1]
[2]
Initially, ABEM meetings were held in Ana Maria Levy's apartment. As the group expanded,
a permanent space was established at Lar Escola São Francisco, and later, additional
chapters were created in Rio de Janeiro and other cities. Organizations such as ABEM
play an essential role in providing resources, support, and advocacy for MS patients,
increasing the visibility of chronic illnesses, and fostering a more empathetic and
informed society.[7]
In conclusion, Jacqueline du Pré's legacy extends beyond her invaluable contributions
to classical music. Her story has inspired the creation of significant platforms for
discussion and confrontation of MS, fostering greater understanding and support for
those affected worldwide. Through art, science, and solidarity, the fight against
multiple sclerosis continues, echoing du Pré's resilient spirit. By intertwining her
life and illness, du Pré and her representation demonstrate the power of art to transcend
the personal, leaving a deep and lasting impact on society.
Bibliographical Record
Diogo Haddad-Santos, Filipi Fim Andreão, Filipe Virgilio Ribeiro, Karlos Daniell Araújo
dos Santos, Fernanda Herculano, Guilherme Sciascia do Olival, Rafael Paterno Dias
Carneiro. A cello concert in Brazilian lands: the life, art, and disease of Jacqueline
du Pré. Arq Neuropsiquiatr 2025; 83: s00451811726.
DOI: 10.1055/s-0045-1811726
