Local injection of N-butyl-2-cyanoacrylate has been used successfully for the hemostatic
treatment of bleeding gastric varices [1]. Various complications associated with the procedure have been reported [2]. The prevalence of infectious complications could range from 4.3 % to 50 %, and
most are transient and uneventful [3]. Because prolonged and persistent septic complications have been rarely reported,
the appropriate strategy of management in this situation has become a challenge.
A 70-year-old man and a 61-year-old woman with a history of liver cirrhosis underwent
local injection of N-butyl-2-cyanoacrylate for bleeding gastric varices. Prolonged
and persistent fever with bacteremia occurred after the procedure despite systemic
antibiotic administration for more than 1 month. Initial evaluations to determine
the source of sepsis were unremarkable in both patients.
A gallium scan for unknown fever was carried out and revealed a significant hot spot
in the upper middle abdomen in the first patient ([Figure 1]) but not in the second. We repeated esophagogastroduodenal endoscopy and endoscopic
ultrasonography (EUS) in both patients. The first patient had incomplete obturation
of perigastric varices flow ([Figure 2 a]). During the procedure, the injected histoacryl cast fell apart ([Figure 2 b]). Fever subsided dramatically on the same day. In the second patient, we found a
soft tissue ball in the gastric varices with blood flow passing through ([Figure 3 a, b]). We injected an additional amount of N-butyl-2-cyanoacrylate to obturate the flow
of gastric varices completely ([Figure 3 c]), and then fever subsided.
Figure 1 Whole-body gallium scan showing a hot spot located at the upper middle abdomen, which
was consistent with the location of gastric varices injection.
Figure 2 a Endoscopic ultrasonography (EUS) showing incomplete obturation of perigastric varices
flow. b Endoscopic view of gastric fundus after EUS procedure showing gastric varices after
histoacryl obturation (thin arrow) and a dropped cast (thick arrow).
Figure 3 Endoscopic ultrasonography (EUS) and endoscopic studies before and after repeat histoacryl
injection. a Endoscopic view of gastric fundus showed severe gastric varices with previous histoacryl
injection. b EUS showed large collateral vessels on the perigastric area and a soft tissue ball
in the gastric varices with blood flow passing through. c Endoscopic view of gastric varices after repeat histoacryl injection. d EUS view showing no blood flow passing through the vegetation after complete histoacryl
obturation.
From our cases, the cause of persistent fever and bacteremia after tissue adhesive
injection could be incomplete obliteration of gastric varices with bacterial seeding
on the soft tissue or adhesive cast. Gallium scan may be helpful in identifying the
injection site as the infectious source, as was the case in our first patient. EUS
can be used to evaluate residual blood flow of gastric varices, perigastric collateral,
and to identify the possible infectious loci [4]. Repeated and complete obliteration of gastric varices are needed to cure this complication
in addition to prolonged antibiotic treatment. Another option could be to wait for
spontaneous expulsion of the cast and repair of the tissue defect. Surgical intervention
should be delayed if clinical circumstances allow [5].
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