INTRODUCTION
Pancreatitis is associated with high morbidity and mortality. Pseudoaneurysm is most
feared complication of chronic pancreatitis, noted in 10% of patients. The risk of
rupture is as high as 50%, and the mortality after rupture is about 15%–40%.[1 ],[2 ] Therefore, it requires a prompt diagnosis and management. Diagnostic modalities
such as computed tomography (CT) help in picking up the lesion and delineating the
vessel of origin. Digital subtraction angiography (DSA) and subsequent coil embolization
are standard treatment protocol to manage such patients and avoid uncontrolled bleeding.
Occasionally, coil embolization is not feasible due to inaccessible vascular territory
or short neck of pseudoaneurysm. Further, some pseudoaneurysms may be angiographically
occult and are seen on ultrasound or CT only. In such cases, ultrasound or CT guided
percutaneous thrombin injection can be performed. Endoscopic ultrasound (EUS)-guided
thrombin injection is a new development in this realm, especially in those patients
where the visualization of the lesion is difficult on transabdominal ultrasound. This
modality avoids the need for surgery and the associated morbidity, however, it requires
expertise. We report a case where gastroduodenal artery (GDA) pseudoaneurysm were
occluded using EUS-guided thrombin injection.
CASE REPORT
A 43-year-old male presented to us with complaints of jaundice, pain abdomen, and
shortness of breath. He was a chronic smoker and had history of significant ethanol
intake. After evaluation, diagnosis of ethanol-induced chronic pancreatitis with complications
in the form of walled-off pancreatic necrosis (WOPN), common bile duct (CBD) stricture,
left-sided pleural effusion, and GDA pseudoaneurysm [Figure 1 ] was made. Patient underwent endoscopic retrograde cholangiopancreatography and a
7 Fr × 10 cm double pigtail stent was placed for CBD stricture to relieve jaundice.
Following this, a surgical gastroenterology consultation was taken for operability,
however, due to poor nutritional status (body mass index 2) and associated WOPN with
pleural effusion, surgeon deferred surgery, and conservative management was advised.
Following this, interventional radiology consultation was taken for embolization of
GDA pseudoaneurysm, but it was deferred in view of involvement of a large caliber
vessel which if embolized may cause dislodgement of foam particles leading to systemic
embolization and serious complications. In our center, in hemodynamically stable patients,
the usual approach to manage pancreatitis-related pseudoaneurysm is to perform CT
angiography for localization of pseudoaneurysm. Subsequently, DSA is performed, and
selective cannulation of the culprit vessel is done. If one can reach the pseudoaneurysm,
coil embolization is done by occluding the back door, neck, and front door of the
pseudoaneurysm. This prevents any collateral refilling of pseudoaneurysm. However,
in our case, coil embolization could not be done due to above-mentioned reasons.
Figure 1: Gastroduodenal artery pseudoaneurysm on computed tomography angiography
As this patient had pancreatic left pleural effusion, a possibility of pancreatic
duct disruption in tail region was kept, and pancreatic duct stenting was planned.
However, during pancreatic duct cannulation, there was a gush of blood from pancreatic
orifice, most likely the aneurysm bleed, which was temporarily managed with mechanical
compression using basket and local injection of epinephrine. We, therefore, planned
EUS-guided thrombin injection to treat this pseudoaneurysm.
Technique of endoscopic ultrasound-guided thrombin injection
An experienced gastroenterologist, who has got experience in EUS-guided procedures,
performed this procedure. The procedure was performed without any anesthesia. Initially,
EUS was performed using curved linear array transducer (Olympus-GF-UCT180) in conjunction
with EVIS EXERA CLV-180 light source (Olympus Medical System Corp., Tokyo, Japan),
pseudoaneurysm was localized, and shortest path was chosen to target the pseudoaneurysm
[Figure 2 ]. We used the thrombin component of Religare ® Kit (Reliance), containing thrombin
500 IU/ml. Before targeting the pseudoaneurysm, thrombin component of this kit was
reconstituted with 1 ml of calcium chloride, and this thrombin solution was further
diluted with 6 ml normal saline to a total of 7 ml so that each milliliter of reconstituted
solution contains approximate 71 IU of thrombin. Further, each milliliter of reconstituted
thrombin was transferred to 1 ml insulin syringe, and 7 such thrombin-loaded syringes
were kept ready before the procedure. Using 22-gauge Echo Tip Ultra EUS needle (Cook
Medical Endoscopy, IN, United States), pseudoaneurysm was punctured under EUS guidance,
and then, thrombin was injected in aliquots of 71 IU till the pseudoaneurysm became
echogenic resulting in thrombosis [Figure 3 ]. Under color Doppler, the success of thrombosis was confirmed, and the needle was
removed when loss of Doppler signal was seen inside the pseudoaneurysm sac. The entire
procedure from start of localization of pseudoaneurysm to complete thrombosis of pseudoaneurysm
lasted for about 15 min. After procedure, the patient was monitored closely for signs
of internal bleeding. Next day, check EUS was done that showed complete thrombosis
of pseudoaneurysm. Follow-up after 10 days showed complete occlusion of the pseudoaneurysm
[Figure 4 ].
Figure 2: Endoscopic ultrasound shows pseudoaneurysm of gastroduodenal artery within walled
of pancreatic necrosis with Doppler signal
Figure 3: Endoscopic ultrasound needle 22-gauge-guided injection of thrombin with echogenic
thrombus and loss of Doppler signal
Figure 4: After 10 days, it shows no Doppler signal in pseudoaneurysm
Pancreatic duct was cannulated, and 7 Fr × 10 cm pancreatic stent was successfully
placed. EUS again repeated at 3 months and showed no evidence of pseudoaneurysm [Figure 5 ].
Figure 5: After 3 months, it shows no Doppler signal in pseudoaneurysm
DISCUSSION
Pseudoaneurysm formation is a known vascular complication of pancreatitis. This occurs
due to vessel injury as a result of proteolytic and lipolytic enzymes released during
inflammation and pancreatic necrosis.[3 ] The management of pseudoaneurysm in the setting of pancreatitis is challenging in
view of the associated risk of rupture and hemodynamic compromise, apart from the
increased morbidity of pancreatitis itself.
Diagnostic modality such as CT angiography remains a preliminary imaging modality
in pancreatitis. DSA with coil embolization is the gold standard treatment. This offers
the advantage of avoiding the associated surgical risk; besides, it ensures adequate
thrombosis of the pseudoaneurysm in most cases. However, in situ ations where the
access to pseudoaneurysm is not possible due to previous clipping/tortuous anatomy
or when pseudoaneurysm is not visible on DSA due to slow filling and narrow neck;
angiographic coil embolization may not be feasible. Some pseudoaneurysms are occult
and detected only with other imaging modalities such as CT or EUS. If left alone,
these pseudoaneurysms can rupture or rebleed. The risk of rupture in pancreatic pseudoaneurysms
can been as high as 15%–40%.[1 ] Hence, embolization is necessary to avoid rupture and rebleeding.
Thrombin remains an alternative to coils. It can be instilled directly at bleeding
site, and flow cessation can be assessed. Thrombin is a good alternative in those
cases, which are not feasible by endovascular route. The success of thrombin in embolization
of peripheral pseudoaneurysms as [4 ],[5 ],[6 ] well as those of pancreas [7 ],[8 ],[9 ],[10 ] has been well described in literature. Thrombin can be given through transcutaneous
route using ultrasound or CT guidance. However, in our patient, transabdominal ultrasound
could not delineate the lesion clearly posing great challenge for thrombin instillation.
EUS was the next step as most of these pseudoaneurysms are in the vascular territory
in the vicinity of peripancreatic region. The advantage of EUS lies in clearly delineating
the extent and size of pseudoaneurysm. Instillation of thrombin under EUS guidance
requires a great deal of expertise. Thrombin injection ensures immediate occlusion
of pseudoaneurysm in most of the cases. Response assessment can also be done easily.
Hallmark finding is a complete loss of Doppler signal on EUS. Serial follow-up over
1 month did not reveal rebleeding or rupture in our case. There is scarcity of literature
describing use of EUS-guided thrombin instillation in pancreatic pseudoaneurysm. In
one of the earliest descriptions, Roach et al.[11 ] described EUS-guided thrombin occlusion of a pseudoaneurysm arising from a branch
of superior mesenteric artery in a patient presenting with the upper gastrointestinal
bleed. This was done following failure to embolize angiographically as feeding artery
could not be catheterized. Use of thrombin is recommended in cases of hemodynamically
stable patients with small pseudoaneurysm.[12 ] In addition, it can be used in large lesions as an adjunct to coil embolization.
In hemodynamically unstable patients and those with large pseudoaneurysms or those
with failure after repeated embolization, surgery remains the only option. However,
in the setting of pancreatitis, surgery is associated with a grim outcome. The advent
of thrombin instillation through EUS guidance has opened an altogether new arena for
managing difficult pseudoaneurysms and thereby avoiding associated surgical risk.
This case was unique and possibly the first to the best of my knowledge in our country,
where we used thrombin alone for a large pseudoaneurysm of 4 cm × 5 cm size. Although
one cannot undermine the expertise needed in EUS guidance, it offers new hope to this
special group of patients with pseudoaneurysm, which are inaccessible to therapeutic
angiography or through transabdominal ultrasound.
Limitations of thrombin instillation include the risk of distal thrombosis. This rarely
occurs since thrombin is rapidly diluted and inactivated by the fast flowing blood
stream.[10 ] Immunological reactions such as hypersensitivity reactions are also known to occur.
Recanalization after initial successful thrombosis of pseudoaneurysm is another complication.
Finally, duration of follow-up required after treatment of pseudoaneurysms is not
mentioned in the literature.
Further studies are also needed to provide data regarding efficacy and long-term outcomes.
Financial support and sponsorship
Nil.
