Keywords
Hip pain - inguinal pain - ischiopubic synchondrosis - osteochondritis - Van Neck–Odelberg
Introduction
Van Neck–Odelberg disease, also known as ischiopubic osteochondritis, is only seen
in childhood and is considered a rare cause of pain. It is located in the pelvis,
in the junction between the ischium and the pubic bone and will ossify as a physiological
process before puberty. It is usually an asymptomatic process, but it can be associated
with pain and limitation in movement, due to mechanical stress, creating a challenge
in its diagnosis due to its imagenological similarity to pseudotumoral diseases and
other pathological entities, such as fractures. An early diagnosis will allow adequate
treatment, avoiding unnecessary invasive procedures.
Case Report
A 15-year-old boy consulted our hospital for pelvic pain of 3 months duration; this
pain was constant, non-radiating, predominantly in the right iliac fossa and hypogastrium,
sharp stabbing type, 8/10 in the analogue pain scale, associated with right side gait
limitation, without any other finding on physical examination. The laboratory tests
were within normal limits. A radiography of the hips and magnetic resonance imaging
(MRI) were performed at another institution, which were initially interpreted as a
fracture of the right ischiopubic ramus.
Bone scintigraphy with a fusion of tomographic images (single-photon emission computed
tomography/computed tomography [SPECT/CT]) was requested. Focal increased uptake at
the site of ischiopubic synchondrosis was documented, and a fracture was ruled out.
It correlated with the aforementioned extra-institutional images, in which a prominence
and focal expansion of the middle portion of the right ischiopubic ramus corresponding
to the synchondrosis was identified, associated with an increase in signal intensity
in sequences with T2 information with fat saturation due to bone and adjacent soft-tissue
edema. Findings represent a stress-related lesion at the level of ischiopubic synchondrosis,
diagnostic of ischiopubic osteochondritis, which is also called Van Neck–Odelberg
disease.
Discussion
Pain in the hips in the pediatric age is a diagnostic challenge due to the similar
appearance in the diagnostic images in a wide variety of entities that may have disabling
sequelae in future. Among the most frequent causes of pain are stress fractures, slipped
epiphysis, septic arthritis or osteomyelitis, and bone tumors.
Ischiopubic synchondrosis is a normal temporary joint in the pediatric age during
the development of skeletal maturation, which is located between the ischium and the
pubic ramus, developing symmetrically, consisting of two ossification centers and
a cartilaginous center, with normal bilateral enlargement of the joint during growth
until its final bone fusion at puberty.[1] However, since 1924, ischiopubic osteochondritis, is also called “Van Neck-Odelberg”
disease, named after Odelberg and Van Neck,[2] who first described it. In this disease, the main symptom is pain, which can cause
a limitation in movement or limp, as a result of mechanical stress due to excessive
traction of the ischiotibial muscles at ischiatic tuberosity[3], which will produce a delayed closure of this synchondrosis, and as a consequence,
an inflammatory reaction and a delay in the cartilage junction and the ossification
centers;[4] this process occurs unilaterally, mainly in older children, associated with sports,
mostly affecting the left or nondominant leg, since it receives the weight of the
body balance and the greater tension of the adductor, iliopsoas and twin muscles,[3] its diagnosis is a challenge being a rare pathology.
On x-ray [Figure 1] and CT of the hip, a fusiform shaped hyperostosis will be observed, with a hypodense
area inside and bone callus formation secondary to increase in tension that will enlarge
the joint, which creates the appearance of a pseudotumor due to its morphology; cystic
areas of absorption and an increase in density can also be seen later.[5]
Figure 1 Anteroposterior and right lateral hip X-ray (a and b). On the right, a well-defined,
rounded radiolucent area with sclerosis inside is identified, which represents ischiopubic
synchondrosis
MRI [Figure 2] can provide early and more sensitive diagnosis. There is an increase in signal intensity
in sequences with T2 information with fatty saturation or short-tau inversion recovery,
secondary to bone edema at the site of synchondrosis, with evidence of bone bridges
and cartilage inside. These not only help rule out a neoplasm, such as Ewing's sarcoma,
and increase the diagnostic certainty,[6] but might be misinterpreted due to inexperience.
Figure 2 Axial images T1, short-tau inversion recovery and T2. (a.c) The enlarged right ischiopubic
synchondrosis is identified with increase in the signal in sequences with T2 information
due to bone edema, with presence of a hypointense central band in its interior along
with bone bridges and signal alteration of adjacent soft tissues due to edema
Bone scintigraphy allows the detection of an increase in focal radiotracer uptake
secondary to an abnormal early osteogenic activity, and fusion with tomographic images
(SPECT/CT) [Figure 3] allows a better anatomical correlation which increases its sensitivity in the diagnosis
of a stress-related lesion involving the ischiopubic synchondrosis.[7],[8] Knowledge of this pathology helps differentiate from a avoid being confused with
fracture, posttraumatic osteolysis, infection, or tumor in symptomatic children that
may lead to unnecessary invasive procedures.
Figure 3 Bone scan 99mTc-MDP (anterior, posterior and axial) with single-photon emission computed tomography/computed
tomography. (a.e) Increased uptake area in lower ischiopubic branch which in fusion
images confirm the site of the ischiopubic synchondrosis
The course of the disease is benign, and improvement occurs in weeks or months with
adequate conservative treatment; changes in the images can last for a longer time
until complete ossification of the joint.[9]
Conclusion
Ischiopubic osteochondritis, or Van Neck–Odelberg disease, is a rare and little known
entity in pediatric age, and is difficult to diagnose. Even though it is a pathology
with a conservative treatment and a good prognosis, it might be misdiagnosed and lead
to unnecessary invasive management. Knowledge of anatomy and physiology of this normal
temporary joint, in addition to the typical findings of this pathology on the different
imaging modalities, can help accurate identification and differential diagnosis of
this pathology.