DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 56 · January 2018 DOI: 10.1055/s-007-35562

Deutsche Arbeitsgemeinschaft zum Studium der Leber
34. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Hamburg, 26.–27.01.2018

Kongresspräsident: Prof. Dr. Ansgar Lohse
Abstracts (HTML) List of Authors
A4.4
Ostroumov, D; Wingerath, J; Woller, N; Gürlevik, E; Manns, M; Longerich, T; Kubicka, S; Kühnel, F; Wirth, T: Investigation of exhausted tumor-specific CD8 T cells in orthotopic hepatocellular carcinoma mouse model
A4.5
Castven, D; Becker, D; Czauderna, C; Wilhelm, D; Andersen, J; Strand, S; Heilmann-Heimbach, S; Roth, W; Hartmann, N; Straub, B; Mahn, F; Franck, S; Pereira, S; Hartmann, M; Haupts, A; Vogel, A; Wörns, M; Weinmann, A; Heinrich, S; Lang, H; Thorgeirsson, S; Galle, P; Marquardt, J: Application of Patient-Derived Liver Cancer Cells in Personalized Treatment Approach: Phenotypic Characterization and Therapeutic Target Identification
A4.6
Lozanovski, V; Khajeh, E; Fonouni, H; Pfeiffenberger, J; Haken, R von; Brenner, T; Mieth, M; Michalski, C; Weiss, K; Mehrabi, A: Major Extended Donor Criteria predict graft failure and patient mortality after liver transplantation – call for caution
A4.7
Mohs, A; Kuttkat, N; Otto, T; Sonntag, R; Youssef, S; de Bruin, A; Trautwein, C: Deletion of MyD88 in non-parenchymal cells, but not in parenchymal cells attenuates the progression of hepatocellular carcinoma
A4.8
Brandt, E; Fischer, P; Wirtz, T; Trautwein, C; Sahin, H; Berres, M: Genetic deletion of Cxcr3 triggers HCC progression in mice by mediating accumulation of anti-inflammatory/pro-angiogenic tumor associated macrophages
A4.9
Yu, X; Steinheuer, L; Schmiel, M; Ulmer, B; Eischeid, H; Büttner, R; Odenthal, M; Wang, L: The epigenetic writer LSD1 controls hepatic cell cycle progression by alteration of global expression profiles and protein signatures
A4.10
Thomann, S; Weiler, S; Dittmer, M; Kazdal, D; Marquard, S; Roessler, S; Sticht, C; Gretz, N; Mogler, C; Ball, C; Glimm, H; Ryschich, E; Schirmacher, P; Breuhahn, K: Dynamic communication patterns determine the endothelial cell rheostat in liver capillarization and tumorigenesis
A4.11
Bogner, A; Reissfelder, C; Striebel, F; Rahbari, M; Büchler, M; Weitz, J; Rahbari, N: Liver macrohemodynamics predict ascites and liver failure after hepatectomy: A prospective study
A4.12
Knaub, M; Thomann, S; Weiler, S; Schirmacher, P; Breuhahn, K: YAP (Yes-Associated Protein) induces PRC2 (Polycomb Repressive Complex 2) proteins to regulate histone methylation
A4.13
Luiken, S; Bieg, M; Goeppert, B; Brors, B; Pusch, S; Longerich, T; Schirmacher, P; Roessler, S: The role of mutations in NOTCH signaling pathway components in liver carcinogenesis
A4.14
Dietrich, P; Freese, K; Thasler, W; Hellerbrand, C: Expression of different histone deacetylases and functional effects of histone deacetylase inhibitors in hepatocellular carcinoma
A4.15
Sonntag, R; Mohs, A; Kohlhepp, M; Haas, U; Lambertz, D; Trautwein, C; Liedtke, C: Interventional gene targeting of cell cycle regulators identifies Cyclin E1 as a suitable target for attenuating hepatocellular carcinoma progression
A4.16
Loosen, S; Binnebösel, M; Klink, C; Ulmer, T; Longerich, T; Trautwein, C; Roderburg, C; Neumann, U; Luedde, T: Soluble urokinase plasminogen activator receptor (suPAR) represents a novel biomarker for patients undergoing resection of colorectal liver metastases
A4.17
Lozanovski, V; Khajeh, E; Pfeiffenberger, J; Fonouni, H; Brenner, T; Haken, R von; Mieth, M; Michalski, C; Weiss, K; Mehrabi, A: Is allocation of liver grafts based on major Extended Donor Criteria plausible? Proposal of an allocation algorithm
A4.18
Yang, C; Rahbari, M; Büchler, M; Weitz, J; Reissfelder, C; Rahbari, N: CD105 CD146 circulating endothelial cells facilitate liver regeneration and predict posthepatectomy liver failure in humans
A4.19
Neuberger, M; Weiss, K; Mehrabi, A; Stremmel, W; Gotthardt, D; Sommerer, C; Rupp, C: Effekt der Mycophenolsäure auf die Aktivität der Inosinmonophosphatdehydrogenase (IMPDH) bei Lebertransplantierten
A4.20
Atanasov, G; Feldbrügge, L; Benzing, C; Krenzien, F; Schierle, K; Robson, S; Splith, K; Pascher, A; Bahra, M; Pratschke, J; Schmelzle, M: Angiogenic miRNAs, angiopoietin axis and related TIE2-expressing monocytes affect outcome in cholangiocarcinoma
A4.21
Pinna, F; Pellegrino, R; Neumann, A; Baues, J; Schirmacher, P; Longerich, T: Imbalance of scaffold proteins IQGAP1/IQGAP2 in Liver Cancer
A4.22
Goeppert, B; Roessler, S; Renner, M; Singer, S; Mehrabi, A; Pathil, A; Czink, E; Köhler, B; Springfeld, C; Pfeiffenberger, J; Rupp, C; Weiss, K; Schirmacher, P; Knebel Doeberitz, M; Kloor, M: Low Frequency of Mismatch Repair Deficiency in a Large Cohort of Non-liver fluke associated Cholangiocarcinomas
A4.23
Wormser, L; Bosserhoff, A; Hellerbrand, C; Dietrich, P: The long non-coding RNAs lncRNA-ADM-2 and lncRNA-NBPF3-9 outline potential novel targets for hepatocellular carcinoma
A4.24
Schönfels, W von; Will, O; Schniewind, B; Beckmann, J; Becker, T; Hampe, J; Schafmayer, C: Electrosurgical liver resection has a superior regeneration outcome as compared to en-bloc ligation in a novel model of partial hepatectomy in mice
A4.25
Pellegrino, R; Ticconi, F; Skawran, B; Castoldi, M; Neumann, A; Pinna, F; Schirmacher, P; Costa, I; Longerich, T: Defining the LINC00152-modulated ceRNA network in human hepatocellular carcinoma
A4.26
Deutschmann, K; Reich, M; Lang, A; Piekorz, R; Häussinger, D; Keitel, V: Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
A4.27
Helmrich, N; Churin, Y; Tschuschner, A; Roderfeld, M; Roeb, E: Reduktion Karzinogenese-assoziierter Signalwege durch pharmakologische Inhibierung des Cannabinoid-Rezeptor-1 im murinen Abcb4-/- Modell
A4.28
Zimmermann, A; Darstein, F; Abel, F; Hoppe-Lotichius, M; Lautem, A; Schad, A; Mittler, J; Vollmer, J; Lang, H; Galle, P; Zimmermann, T; Schuppan, D: Donor but not recipient CRS predicts fibrosis progression after liver transplantation in a large cohort of HCV-positive and negative patients
A4.30
Loosen, S; Roderburg, C; Trautwein, C; Neumann, U; Luedde, T: CEA but not CA19 – 9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma
A4.31
Ribback, S; Sonke, J; Lohr, A; Frohme, J; Peters, K; Holm, J; Cigliano, A; Peters, M; Calvisi, D; Dombrowski, F: Hepatocellular clear cell foci after combined intraportal pancreatic islet transplantation and knockout of chREBP in diabetic mice
A4.32
Gaza, A; Hellerbrand, C; Bosserhof, A; Dietrich, P: Novel feedback inhibition of the let-7 microRNA regulator and stem cell marker Lin 28 homolog A by tumorsuppressor miR-622 in hepatocellular carcinoma
A4.33
Fritz, V; Hellerbrand, C; Bosserhoff, A; Dietrich, P: A novel Krueppel-like factor 12/Interleukin-6 signal transducer – microRNA-188-5 p interaction reveals therapeutic targets for hepatocellular carcinoma
A4.34
Dietrich, P; Koch, A; Bosserhoff, A; Hellerbrand, C: Sorafenib-resistance is mediated by a novel Kirsten rat sarcoma-microRNA-axis in hepatocellular carcinoma
A4.35
Bednarsch, J; Czigany, Z; Schlebusch, I; Schöning, W; Ulmer, T; Amygdalos, I; Morales Santana, D; Meister, F; Böcker, J; Neumann, U; Lurje, G: Hilar en-bloc resection for perihilar cholangiocarcinoma (PHCC); a single-center experience
A4.36
Yuan, X; Li, J; Coulouarn, C; Dooley, S; Weng, H: SOX9 is a crucial transcription factor determining intrahepatic cholangiocarcinoma resistance to chemotherapy
A4.37
Ghamarnejad, O; Fonouni, H; Khajeh, E; Aydogdu, E; Longerich, T; Mehrabi, A: Impact of modern topical sealants on histopathological changes after hepatectomy: an experimental porcine study
A4.38
Itzel, T; Evert, M; Teufel, A: Hepamine – A Liver Disease Microarray Database, Visualization Platform and Data-Mining Resource
A4.39
Wehmeyer, M; Dammermann, W; Seiz, O; Zinser, M; Galante, A; Lohse, A; Sterneck, M; Nashan, B; Herden, U; Lüth, S: Chronic pancreatitis in patients with liver cirrhosis negatively affects graft survival after liver transplantation
A4.40
Czauderna, C; Koch, S; Pilz, L; Franck, S; Wörns, M; Lang, H; Kloeckner, R; Galle, P; Marquardt, J; Weinmann, A: Alpha-fetoprotein changes prior to therapy predict overall survival of patients with hepatocellular carcinomas
A4.41
Heits, N; Brosch, M; Herrmann, A; Behrens, R; Röcken, C; Schrem, H; Kaltenborn, A; Klempnauer, J; Kreipe, H; Reichert, B; Lenschow, C; Wilms, C; Wolters, H; Wardelmann, E; Seehofer, D; Buch, S; Zeissig, S; Pannach, S; Raschzok, N; Dietel, M; Schoenfels, W von; Hinz, S; Teufel, A; Evert, M; Franke, A; Becker, T; Braun, F; Hampe, J; Schafmayer, C: Evolutionary distance predicts recurrence after liver transplantation in multifocal hepatocellular carcinoma
A4.42
Juratli, M; Bechstein, W; Schnitzbauer, A: Circulating tumor cells dynamic as therapy surveillance of liver tumor surgery
A4.43
Fischer, L; Wege, H; Del Pino, S; Li, J: Sicherheit und Praktikabilität der laparoskopischen Leberresektion (LLR) des Hepatozellulären Karzinoms (HCC) bei Leberzirrhose
A4.44
Holzer, K; Drucker, E; Waldburger, N; Eiteneuer, E; Breuhahn, K; Ori, A; Schirmacher, P; Singer, S: Ganglioside GM2 activator (GM2A) is as a novel pro-survival p53 target in hepatocellular carcinoma
A4.45
Reusswig, F; Gowert, N; Klier, M; Reich, M; Donner, L; Keitel-Anselmino, V; Häussinger, D; Elvers, M: Platelet defects upon surgical liver disease models in mice
A4.46
Zimmer, V; Reichert, M; Krawczyk, M; Weber, S; Lammert, F: Haemochromatosis (HFE) gene variation and cholangiocarcinoma risk
A4.47
Yu, X; Steinheuer, L; Schmiel, M; Ulmer, B; Eischeid, H; Buettner, R; Odenthal, M; Wang, L: The lysine-specific histone demethylase LSD1 controls cell cycle progression in liver fibrosis and cancer by alteration of protein expression profiles
A4.48
Tsui, T; Heumann, A; Wellge, B; Izbicki, J: Efficacy of ALPPS procedure versus portal vein embolization for hypertrophy of future liver remnant in right trisectionectomy: quality and outcome
A4.49
Padem, S; Quack, T; Grevelding, C; Churin, Y; Tschuschner, A; Roderfeld, M; Roeb, E: Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell
A4.50
Felden, J von; Schulze, K; Ittrich, H; Gil-Ibanez, I; Fründt, T; Krause, J; Karkmann, K; Lohse, A; Wege, H: Regorafenib after progression on Sorafenib for advanced HCC
A4.51
Duong, S; Manns, M; Wirth, T: Heterologous immune vaccination induces specific therapeutic CD8 T-cell immune responses against tumor-associated antigens expressed in HCC
A4.52
Reichert, M; Bolik, J; Bergmann, J; Baumann, N; Mittrücker, H; Wunderlich, F; Rose-John, S; Schmidt-Arras, D: ADAM17-induced signaling pathways in the liver are essentially involved in DNA-damage and HCC formation
A4.53
Dietrich, P; Freese, K; Sommer, J; Mahli, A; Hellerbrand, C; Bosserhoff, A: Combined effects of polo-like kinase 1 and harvey rat sarcoma in hepatocellular carcinoma reveal novel therapeutic strategies
A4.54
Kaul, F; Hellerbrand, C; Bosserhoff, A; Dietrich, P: TNF receptor superfamily member 10 d is a novel diagnostic and therapeutic target in hepatocellular carcinoma progression and sorafenib-resistance
A4.55
Huebener, P; Sterneck, M; Bangert, K; Lohse, A; Kluge, S; Fischer, L; Fuhrmann, V: Clinical stabilization of ACLF patients before orthotopic liver transplantation predicts post-transplant survival
A4.56
Tauber, C; Hofmann, M; Thimme, R: MAGE-specific CD8 T cells are not exhausted in HCC patients
A4.57
Bednarsch, J; Förster, M; Schöning, W; Ulmer, T; Amygdalos, I; Czigany, Z; Morales Santana, D; Meister, F; Böcker, J; Kroh, A; Kroy, D; Neumann, U; Lurje, G: Multimodal treatment modalities are associated with improved long-term outcome in patients with recurrent hepatocellular carcinoma
A4.58
Bednarsch, J; Czigany, Z; Sharmeen, S; Schöning, W; Ulmer, T; Binnsbösel, M; Amygdalos, I; Morales Santana, D; Meister, F; Böcker, J; Neumann, U; Lurje, G: Comparative outcome analysis of two-stage hepatectomy with PVE (TSH/PVE) versus ALPPS for patients with colorectal liver metastases (CRLM)
A4.59
Golriz, M; Ghamarnejad, O; Khajeh, E; Sabagh, M; Mieth, M; Hoffmann, K; Ulrich, A; Hackert, T; Weiss, K; Schirmacher, P; Büchler, M; Mehrabi, A: Preoperative thrombocytopenia may predict poor surgical outcome after extended hepatectomy
A4.60
Abbasi, S; Golriz, M; Fathi, P; Majlesara, A; Brenner, T; Mehrabi, A: Does acid-base equilibrium correlate with remnant liver volume during stepwise liver resection?
A4.61
Tóth, M; Wan, S; Weiler, S; Schmitt, J; Sticht, C; Gretz, N; Schirmacher, P; Breuhahn, K: MPP5 (Membrane Palmitoylated Protein 5), a novel upstream regulator of yes-associated protein (YAP) and its paralogue TAZ
A4.62
Kloeckner, R; Steinle, V; Mähringer-Kunz, A; Koch, S; Schotten, S; Lang, H; Düber, C; Galle, P; Marquardt, J; Wörns, M; Weinmann, A: Liver vein infiltration in patients with hepatocellular carcinoma in a large German cohort
A4.63
Czigany, Z; Morales Santana, D; Schöning, W; Ulmer, T; Andert, A; Bednarsch, J; Amygdalos, I; Meister, F; Böcker, J; Grib, V; Isfort, P; Liebl, M; Kroy, D; Neumann, U; Lurje, G: Dunbar syndrome in liver transplantation: results of a single center matched-pair analysis and a European survey study
A4.64
Ehlting, C; Wolf, S; Hahnel, M; Böhmer, O; Albrecht, U; Gaestel, M; Häussinger, D; Bode, J: The inflammatory response and acute phase reaction in the liver upon LPS-treatment or partial hepatectomy is controlled by the MAPKAP kinases 2 and 3
A4.65
Chen, X; Evert, M; Dombrowski, F; Ribback, S; Liu, X; Song, X; Utpatel, K; Calvisi, D: The CDK4/6 inhibitor Palbociclib and the mTOR inhibitor MLN0128 are effective for the treatment of experimental intrahepatic cholangiocarcinoma
A4.66
Evert, K; Zhang, S; Fan, B; Che, L; Pilo, M; Cigliano, A; Ribback, S; Dombrowski, F; Chen, X; Evert, M; Calvisi, D: The pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
A4.67
Bildstein, M; Hellerbrand, C; Bosserhoff, A; Dietrich, P: Muscle RAS oncogene homolog is a novel therapeutic target gene contributing to hepatocellular carcinoma progression and sorafenib-resistance
A4.68
Ungermann, E; Aschenbrenner, E; Pollinger, K; Kunst, C; Müller, M: p63 is a regulator of microRNA expression in hepatocellular carcinoma
A4.69
Kaser, L; Bender, M; Aschenbrenner, E; Pollinger, K; Kunst, C; Müller, M: Regulation of microRNA expression by p73-isoforms in hepatocellular carcinoma
A4.70
Golriz, M; Ghamarnejad, O; Khajeh, E; Hoffmann, K; Mehrabi, A: Predictive role of perioperative platelet count on posthepatectomy liver failure and mortality: a systematic review and meta-analysis
A4.71
Koch, M; Marget, M; Sterneck, M; Thude, H; Nashan, B: Limited impact of pre-existing donor specific HLA antibodies on long term survival after first adult liver transplantation
A4.72
Khajeh, E; Golriz, M; Ashrafi, M; Majlesara, A; Flechtenmacher, C; Mehrabi, A: Establishing a Porcine Model of Small for Size Syndrome following Liver Resection
A4.73
Majlesara, A; Golriz, M; Ghamarnejad, O; Mehrabi, A: The stand of portal vein arterialization in hepatobiliary surgery: a systematic review
A4.74
Juratli, M; Schnitzbauer, A; Blaheta, R; Bechstein, W: The role of α2, αv and β1 Integrins in cell growth of hepatocellular carcinoma cells in vitro
A4.75
Ammar Mohamed, F; Hammad, S; Dooley, S: Increase HCC proliferation with TGF-βR1 inhibition and TLR7 stimulation; are they two faces for one coin?
A4.76
Wiltberger, G; Lange, U; Hau, H; Seehofer, D; Krenzien, F; Benzing, C; Atanasov, G; Pratschke, J; Neumann, U; Robson, S; Schmelzle, M: Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma
A4.77
Dietrich, P; Freese, K; Fritz, V; Lang, S; Thasler, W; Bosserhoff, A; Hellerbrand, C: The role of mechanistic target of rapamycin complex 2-component RICTOR in hepatocellular carcinoma progression and sorafenib-resistance
A4.79
Hempel, M; Hsu, M; Stock, P; Christ, B: Reduzierte Proliferationsraten transplantierter Hepatozyten verhindern eine effiziente Repopularisierung in seneszenten Rattenempfängerlebern
A4.80
Pereira, S; Rodrigues, L; Častven, D; Mahn, FL; Dooley, S; Meindl-Beinker, NM; Lang, H; Grimminger, P; Galle, P; Marquardt, J: Deciphering the Role of Transforming Growth Factor Beta (TGF-β1&2) during Tumor Promotion and Suppression in Primary Liver Cancer
A4.81
Bozko, P; Scholta, T; Bui, K; Toulany, M; Rodemann, H; Malek, N: Notch1-Cyclin E-p27kip1 and RAD17 form a network of proteins which control cellular proliferation and DNA damage response in cholangiocarcinoma
A4.82
Sandmann, L; Dörge, P; Berg, C; Schwarz, J; Welzel, T; Vermehren, J; Weiss, K; Langel, J; Sterneck, M; Wulffen, M von; Manns, M; Wedemeyer, H; Hardtke, S; Hahn, T von: Treatment strategies for patients with decompensated liver cirrhosis due to HCV infection – Antiviral treatment or liver transplantation first?
A4.83
Grützmann, K; Krimmer, M; Thimme, R; Trantham, P; Penny, S; Curbishley, S; Millar, D; Speers, E; Adams, D; Heather, J; Meiß, F; Rafei-Shamsabadi, D; Casetti, F; Shabanowitz, J; Hunt, DF; Cobbold, M; Büttner, N: The role of phosphopeptide neoantigens in cancer immunotherapy