DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 57 · January 2019 DOI: 10.1055/s-008-42145

35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)

Heidelberg, 22.–23.02.2019
Kongresspräsident: Prof. Dr. Ralf Bartenschlager


P4.1
Araos, J; Cai, C; Gaitantzi, H; Rahbari, N; Ebert, MP; Breitkopf-Heinlein, K: Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
P4.2
Backu, E; Aschenbrenner, E; Pollinger, K; Schlosser, S; Gülow, K; Kunst, C; Müller-Schilling, M: Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
P4.3
Brandt, EF; Köhncke, J; Heinrichs, D; Wirtz, TH; Fischer, P; Longerich, T; Trautwein, C; Sahin, H; Berres, ML: Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
P4.4
Brückner, S; Koch, M; Lieshout, R; Verstegen, M; van der Laan, L; Pampaloni, F; Christ, B: Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
P4.5
Castven, D; Becker, D; Czauderna, C; Wilhelm, D; Andersen, JB; Strand, S; Hartmann, M; Heilmann-Heimbach, S; Roth, W; Hartmann, N; Straub, BK; Mahn, F; Franck, S; Pereira, S; Haupts, A; Vogel, A; Wörns, M; Weinmann, A; Heinrich, S; Lang, H; Thorgeirsson, SS; Galle, PR; Marquardt, J: Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
P4.6
Czauderna, C; Poplawski, A; Castven, D; Heilmann-Heimbach, S; Odenthal, M; Amer, W; Andersen, JB; O'Rourke, C; Binder, H; Ridder, DA; Straub, BK; Galle, PR; Thorgeirsson, SS; Park, YN; Marquardt, JU: Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
P4.7
Deutschmann, K; Reich, M; Lang, A; Piekorz, R; Gertzen, C; Gohlke, H; Häussinger, D; Keitel, V: Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
P4.8
Dropmann, A; Ming, T; Dabiri, Y; Cheng, X; Ebert, MP; Wölfl, S; Meindl-Beinker, NM; Dooley, S: Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
P4.9
Drucker, E; Holzer, K; Pusch, S; Calvisi, DF; Eiteneuer, E; Herpel, E; Goeppert, B; Roessler, S; Ori, A; Schirmacher, P; Breuhahn, K; Singer, S: Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
P4.10
Duong, S; Nimanong, S; Ostroumov, D; Falk, CS; Manns, MP; Kühnel, F; Wirth, TC: Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
P4.11
Duret, D; Heinrich, S; Wörns, MA; Jakubowski, S; Roth, W; Straub, BK: Steatosis and associated proteins in hepatocellular adenoma
P4.12
Erdem, M; Möckel, D; Jumpertz, S; John, C; Fragoulis, A; Springer, J; Lurje, G; Lammers, T; van der Kroft, G; Gremse, F; Cramer, T: An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
P4.13
Evert, K; Qiao, Y; Wang, J; Karagoz, E; Song, X; Xu, M; Che, L; Tao, J; Wang, B; Monga, SP; Chen, X; Evert, M; Calvisi, DF: Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
P4.14
Feder, S; Spirk, M; Pohl, R; Rein-Fischboeck, L; Bruckmann, A; Haberl, EM; Buechler, C: Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
P4.17
Köhncke, J; Wirtz, TH; Holland, C; Brandt, EF; Ritz, TP; Heinrichs, D; Fischer, P; Trautwein, C; Longerich, T; Saez-Rodriguez, J; Berres, ML: Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
P4.18
Lang, S; Kasper, P; Steffen, HM; Martin, A; Kütting, F; Schramm, C; Goeser, T; Demir, M: No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
P4.19
Lechler, C; Dong, S; Rösner, T; Manmadhan, S; Kohnke-Ertel, B; Steiger, K; Sage, J; Schmid, RM; Ehmer, U: A targeted screen to identify relevant oncogenes in RAS activated liver cancer
P4.20
Lichtenberger, J; Padem, S; Quack, T; Grevelding, CG; Tschuschner, A; Churin, Y; Roderfeld, M; Roeb, E: Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
P4.21
Loeffler, MA; Kirchner, M; Ji, J; Wei, X; Xiao, Y; Banales, JM; Stenzinger, A; Schirmacher, P; Roessler, S; Goeppert, B: MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
P4.22
Longerich, T; Endris, V; Neumann, O; Rempel, E; Uhrig, S; Kriegsmann, M; Weiss, KH; Mehrabi, A; Weber, TF; Straub, BK; Rosenwald, A; Schulze, F; Budczies, J; Schirmacher, P; Stenzinger, A: RSPO2 gene rearrangement – a new cancer driver in the liver
P4.23
Mester, PI; Aschenbrenner, E; Pollinger, K; Gschwendter, H; Gülow, K; Kunst, C; Müller-Schilling, M: Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
P4.25
Michalski, M; Aschenbrenner, E; Pollinger, K; Müller-Schilling, M; Gülow, K: Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
P4.26
Mohamed, MR; Cubero, FJ; Woitok, MM; Davis, RJ; Trautwein, C: Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
P4.28
Ostroumov, D; Wingerath, J; Woller, N; Gürlevik, E; Manns, MP; Longerich, T; Kubicka, S; Kühnel, F; Wirth, TC: Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
P4.29
Pellegrino, R; Thavamani, A; Calvisi, DF; Neumann, A; Geffers, R; Pinna, F; Schirmacher, P; Nordheim, A; Longerich, T: The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
P4.30
Pereira, S; Luis, ZRL; Castven, D; Mahn, F; Dooley, S; Meindl-Beinker, NM; Strand, D; Lang, H; Grimminger, P; Galle, PR; Marquardt, J: Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
P4.31
Pinna, F; Abadi, Z; Neumann, O; Neumann, A; Klotz, S; De la Torre, C; Gretz, N; Schirmacher, P; Zender, L; Pellegrino, R; Longerich, T: Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
P4.32
Pioronska, W; Nwosu, ZC; Ebert, MP; Dooley, S; Meyer, C: PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
P4.33
Reuken, P; Lutz, P; Casper, M; Al-Herwi, E; Stengel, S; Spengler, U; Stallmach, A; Lammert, F; Nischalke, HD; Bruns, T: The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
P4.34
P4.35
Roderfeld, M; Lichtenberger, J; Wolters, F; Quack, T; Grevelding, CG; Roeb, E: Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
P4.36
Roy, S; Hooiveld, GJ; Seehawer, M; Caruso, S; Pikarsky, E; Tacke, F; Vucur, M; Kather, JN; Zucman-Rossi, J; Trautwein, C; Zender, L; Heikenwälder, M; Roderburg, C; Luedde, T: miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
P4.37
Schmiel, M; Wang, L; Yu, X; Dalvi, P; Macheleidt, I; Buettner, R; Odenthal, M: Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
P4.38
P4.40
Tauber, C; Schultheiss, M; Buettner, N; Llewelly-Laceys, S; Emmerich, F; Zehe, S; Price, DA; Neumann-Haefelin, C; Schmitt-Graeff, A; Hofmann, M; Thimme, R: Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
P4.41
Tolkach, Y; Goltz, D; Kremer, AE; Ahmadzadehfar, H; Bergheim, D; Essler, M; Lam, M; De Keizer, B; Fischer, HP; Kristiansen, G: Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
P4.42
Utpatel, K; Wang, P; Song, X; Shang, R; Xu, M; Che, L; Gordan, J; Hu, X; Chen, X; Evert, M; Calvisi, DF: MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
P4.43
Woitok, MM; Doleschel, D; Zoubek, ME; Kiessling, F; Lederle, W; Cubero, FJ; Trautwein, C: Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
P4.44
Wolff, K; Saborowski, A; Spielberg, S; Erlangga, Z; Beer, B; Becker, D; Dow, LE; Marhenke, S; Woller, N; Unger, K; Schirmacher, P; Manns, MP; Marquardt, JU; Vogel, A; Saborowski, M: Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
P4.45
Wormser, L; Gaza, A; Fritz, V; Hellerbrand, C; Bosserhoff, AK; Dietrich, P: Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
P4.46
Yu, X; Eischeid-Scholz, H; Schmiel, M; Wang, L; Büttner, R; Odenthal, M: MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
P4.47
Zhan, T; Sollors, J; Steinebrunner, N; Schlitt, HJ; Stroszczynski, C; Weiss, KH; Ebert, MP; Teufel, A: Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
P4.48
Zhivkova, N; Schäfer, J; Alizor, H; Ernst, I; Gottfried-Brand, D; Janssen, H; Strand, D; Galle, PR; Strand, S: Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma