DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Ausgabe 01 · Volume 57 · Januar 2019 DOI: 10.1055/s-008-42145

Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)
35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Heidelberg, 22.–23.02.2019

Kongresspräsident: Prof. Dr. Ralf Bartenschlager
Abstracts (HTML) Autorenliste
P5.1
Aliabadi, E; Mix, C; Manns, MP; Kraft, ARM; Cornberg, M: Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
P5.2
Alvarez-Silva, C; Schierwagen, R; Pohlmann, A; Magdaleno, F; Uschner, FE; Ryan, P; Vehreschild, MJGT; Claria, J; Latz, E; Lelouvier, B; Arumugam, M; Trebicka, J: Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
P5.3
Bender, S; Gillich, N; Reuter, A; Mutz, P; Oleksiuk, O; Dächert, C; Binder, M; Bartenschlager, R: Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
P5.4
Bosch, M; Kallin, N; Manske, K; Donakonda, S; Wohlleber, D; Knolle, PA: Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
P5.5
Buechter, M; Gerken, G; Wedemeyer, H; Kahraman, A: Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
P5.6
Dächert, C; Schweinoch, D; Kaderali, L; Binder, M: Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
P5.7
Dammermann, W; Bröker, K; Pischke, S; Vinnemeyer, C; Lüth, S: Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
P5.8
Dudek, M; Pfister, D; Kallin, N; Donakonda, S; Wohlleber, D; Heikenwälder, M; Knolle, PA: Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
P5.9
Ehlting, C; Zimmermann, A; Gaestel, M; Häussinger, D; Bode, JG: Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
P5.10
Ehrlich, S; Wild, K; Smits, M; Zoldan, K; Hofmann, M; Thimme, R; Boettler, T: Type I Interferons promote maintenance and function of follicular T helper cells in vitro
P5.11
Frank, A; Preuß, B; Berg, C; Klein, R: Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)
P5.12
Schumacher, N; Müller, M; Gandraß, M; Lücke, K; Wunderlich, T; Lotter, H; Gagliani, N; Mittrücker, HW; Rehman, A; Rose-John, S; Schmidt-Arras, D: A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
P5.13
Hendricks, L; Hermanussen, L; Giersch, K; Volz, TK; Allweiss, L; Lohse, AW; Sureau, C; Casey, J; Dandri, M; Lütgehetmann, M: Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
P5.14
Hinrichsen, H; Klinker, H; Stoehr, A; John, C; Heyne, R; Klausen, G; Simon, KG; Cornberg, M; Kuhn, M; Naumann, U; Bilzer, M; Guenther, V; Witte, V; Zeuzem, S: High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
P5.15
Ibidapo-obe, O; Stengel, S; Köse, N; Stallmach, A; Bauer, M; Bruns, T: Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
P5.16
Imiela, CS; Churin, Y; Roderfeld, M; Huber, M; Roeb, E: Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
P5.17
Kallin, N; Bosch, M; Manske, K; Donakonda, S; Wohlleber, D; Knolle, PA: Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
P5.18
Kellerer, M; Tiegs, G; Horst, AK: Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation
P5.19
Klopp, A; Philip, B; Pulé, M; Protzer, U; Wisskirchen, K: Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
P5.20
König, V; Manske, K; Kurz, S; Steiger, K; Knolle, PA; Wohlleber, D: Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
P5.21
Kunzmann, L; Schocknecht, T; Poch, T; Kauer, L; Kriz, M; Stein, S; Grewe, I; Preti, M; Hartl, J; Pannicke, N; Peiseler, M; Sebode, M; Weiler-Normann, C; Zenzusi, R; Carambia, A; Lohse, AW; Herkel, J; Schramm, C; Schwinge, D: Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
P5.22
Kurz, S; Brugger, M; Steiger, K; Heikenwälder, M; Knolle, PA; Wohlleber, D: Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
P5.23
Lempp, FA; Sakin, V; Nkongolo, S; Schnitzler, P; Wedemeyer, H; Gal, FL; Gordien, E; Yurdaydin, C; Urban, S: A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
P5.24
Luo, X; Lu, M; Baba, HA; Gerken, G; Wedemeyer, H; Broering, R: The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
P5.25
Manske, K; Schneider, A; Ko, C; Steiger, K; Protzer, U; Knolle, PA; Wohlleber, D: Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
P5.26
Mijočević, H; Karimzadeh, H; Seebach, J; Usman, Z; Al-Mahtab, M; Bazinet, M; Vaillant, A; Roggendorf, M: Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
P5.27
Neumann, K; Heinrich, F; Ochel, A; Tiegs, G: The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
P5.28
Oberhardt, V; Karimzadeh, H; Kiraithe, M; Salimi Alizei, E; Bockmann, JH; Schulze zur Wiesch, J; Budeus, B; Hoffmann, D; Wedemeyer, H; Rodríguez-Frías, F; Casillas, R; Buti, M; Smedile, A; Alavian, SM; Heinold, A; Emmerich, F; Panning, M; Gostick, E; Price, DA; Timm, J; Hofmann, M; Raziorrouh, B; Thimme, R; Protzer, U; Roggendorf, M; Neumann-Haefelin, C: Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
P5.29
Ochel, A; Heinrich, F; Tiegs, G; Neumann, K: The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells
P5.30
Pfefferkorn, M; Schott, T; Felkel, C; Böhm, S; Heyne, R; Glebe, D; Berg, T; van Bömmel, F: Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
P5.31
Piecha, F; Gänssler, JM; Pischke, S; Wehmeyer, MH; Laschtowitz, A; Röder, C; Lohse, AW; Schulze zur Wiesch, J: Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
P5.32
Piecha, F; Gänssler, JM; Wehmeyer, MH; Felden, J von; Laschtowitz, A; Röder, C; Jordan, S; Pischke, S; Lohse, AW; Schulze zur Wiesch, J: Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
P5.33
Piecha, F; Rickert, A; Wehmeyer, MH; Laschtowitz, A; Felden, J von; Röder, C; Bockmann, JH; Pischke, S; Lohse, AW; Schulze zur Wiesch, J: Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
P5.34
Raabe, J; Krämer, B; Lutz, P; Goeser, F; Finnemann, C; Hoffmeister, C; To Vinh, M; Kaiser, K; Manekeller, S; Branchi, V; van Bremen, T; Ludwig-Portugall, I; Strassburg, CP; Spengler, U; Abdallah, AT; Nattermann, J: Human intrahepatic ILC3 may modulate hepatic stellate cell activation
P5.35
Riedl, T; Reisinger, F; Lucifora, J; Neuhaus, K; Prokosch, S; Durantel, D; Dejardin, E; Heikenwälder, M: Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
P5.36
Rosenblatt, M; Teusel, M; Schilling, M; Klingmüller, U; Timmer, J: Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
P5.37
Rufinatscha, K; Stindt, S; Ehlting, C; Bartenschlager, R; Häussinger, D; Bode, JG: Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
P5.38
Rüschenbaum, S; Ciesek, S; Queck, A; Widera, M; Schwarzkopf, K; Brüne, B; Welsch, C; Zeuzem, S; Weigert, A; Lange, C: Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
P5.39
Schakat, M; Bovensiepen, C; Wöstemeier, A; Sebode, M; Lohse, AW; Schramm, C; Herkel, J; Weiler-Normann, C: Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
P5.40
Schelbert, S; Dries, V; Drebber, U; Schindeldecker, M; Weinmann, A; Bartenschlager, R; Schirmacher, P; Roth, W; Straub, BK: Lipid droplets and associated proteins in viral hepatitis
P5.41
Schnieders, A; Lickei, H; Manns, MP; Maasoumy, B; Hardtke, S; Cornberg, M; Kraft, ARM: Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
P5.42
Smits, M; Zoldan, K; Ishaque, N; Gu, Z; Fauvelle, C; Neumann-Haefelin, C; Baumert, T; Emmerich, F; Hofmann, M; Conrad, C; Thimme, R; Boettler, T: Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
P5.43
Stindt, S; Spitzley, S; Bartenschlager, R; Häussinger, D; Bode, JG: Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
P5.44
Tabata, K; Paul, D; Brügger, B; Superti-Furga, G; Bartenschlager, R: Identification of host cell factors involved in hepatitis C virus replication
P5.45
To Vinh, M; Krämer, B; Dobrikova, K; Gotter, C; Raabe, J; Hoffmeister, C; Kaiser, K; Finnemann, C; Wilhelm, C; Schmitt, V; Schwarze-Zander, C; Rockstroh, J; Strassburg, CP; Spengler, U; Nattermann, J: Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
P5.46
Tu, T; Zehnder, B; Levy, M; Micali, G; Tran, L; Dabere, O; Main, N; Shackel, N; Urban, S: Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
P5.47
Twu, WI; Tabata, K; Paul, D; Bartenschlager, R: Role of autophagy in hepatitis C virus replication
P5.48
Usman, Z; Karimzadeh, H; Protzer, U; Roggendorf, M; Frishman, D: HDVdb: Hepatitis D virus database
P5.49
Usman, Z; Mijočević, H; Karimzadeh, H; Al-Mahtab, M; Bazinet, M; Frishman, D; Vaillant, A; Roggendorf, M: Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
P5.50
Velkov, S; Ott, JJ; Protzer, U; Michler, T: Estimation of the genotype distribution within global chronic hepatitis B virus infections
P5.51
Volz, TK; Krstic, T; Allweiss, L; Giersch, K; Lohse, AW; Lütgehetmann, M; Dandri, M: The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
P5.52
Wandrer, F; Liebig, S; Schlue, J; Manns, MP; Schulze-Osthoff, K; Bantel, H: Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
P5.53
Welsch, H; Heine, K; Urban, C; Pichlmair, A; Binder, M: Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
P5.54
Wild, K; Jacobi, F; Smits, M; Zoldan, K; Flecken, T; Lang, J; Ehrenmann, P; Emmerich, F; Hofmann, M; Neumann-Haefelin, C; Thimme, R; Boettler, T: Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
P5.55
Winkler, F; Hensel, N; Wieland, D; Villa, M; Ishaque, N; Conrad, C; Pearce, EL; Thimme, R; Hofmann, M; Bengsch, B: Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
P5.56
Wisskirchen, K; Kah, J; Malo, A; Asen, T; Volz, TK; Allweiss, L; Wettengel, J; Urban, S; Lütgehetmann, M; Bauer, T; Dandri, M; Protzer, U: T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
P5.57
Zhang, Z; Ni, Y; Urban, S: IFN response suppresses HDV persistence during hepatocytes proliferation in vitro
P5.58
Zhang, Z; Trippler, M; Real, CI; Werner, M; Kemper, T; Treckmann, J; Paul, A; Baba, HA; Gerken, G; Wedemeyer, H; Schlaak, J; Lu, M; Broering, R: Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes