DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 63 · January 2025 DOI: 10.1055/s-015-60935


41. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Klinikum rechts der Isar der Technischen Universität München, 14.–15.02.2025

Tagungspräsident:
Prof. Dr. Percy A. Knolle
Abstracts (HTML) Abstracts (PDF) List of Authors
P5.01
Niehaus, Christian; Lietzau, Ayesha; Souleiman, Roni; Maasoumy, Benjamin; Wedemeyer, Heiner; Falk, Christine S.; Kraft, Anke; Cornberg, Markus: Immune activation as a hallmark in liver disease progression
P5.02
von Bülow, Verena; Russ, Lena; Stettler, Frederik; Schramm, Gabriele; Falcone, Franco; Grevelding, Christoph Gero; Roderfeld, Martin; Roeb, Elke: Th2-Associated Cytokines Display an Inverse Relationship with Hepatic Egg Load in Hamsters Infected with Schistosoma mansoni
P5.03
Bauschen, Alina; Langer, Mona; Möhlendick, Birte; Guckenbiehl, Sabrina; Lange, Christian M.: The vitamin D receptor genotype is associated with Vitamin D- and Interleukin-6 concentrations in liver cirrhosis and acute-on-chronic liver failure
P5.04
Deschler, Sebastian; Pohl-Topcu, Junika; Ramsauer, Lukas; Meiser, Philippa; Schenk, Robin P.; Maurer, Hans C.; Kager, Juliane; Erlacher, Sophia; Zink, Joseph; Pistrenko, Karyna; Monte, Enric Redondo; Weber, Julius; Geisler, Fabian; Thorburn, Douglas; Wiedemann, Gabriela; Zischka, Hans; Kleigrewe, Karin; Mogler, Carolin; Böttcher, Jan P.; Knolle, Percy; Schmid, Roland; Böttcher, Katrin: The anti-tumour effector function of mucosal-associated invariant T cells against hepatocellular carcinoma is impaired by fatty acids and aberrant lipid metabolism
P5.05
Springer, Emely; Schneider, Annika; Knolle, Percy; Hüser, Norbert; Laschinger, Melanie; Wohlleber, Dirk: The pivotal role of infected hepatocytes in determining the outcome of antiviral CD8 T cell immunity in the liver
P5.06
Seifert, Leon Louis; Dangas, Georgios; Yu, Yingpu; Freije, Catherine; Hong, Xupeng; Zhang, Mengyin; Quirk, Corrine; Zhou, Yichen; Ogata, Kosuke; Rice, Charles Moen; Schneider, William; Michailidis, Eleftherios; de Jong, Ype: A DNA launch method for HBV infection in human hepatocyte chimeric mice enables isogenic studies of basal-core promoter and precore mutants
P5.07
Averhoff, Pia; Gottwick, Cornelia; Lohse, Ansgar Wilhelm; Carambia, Antonella; Herkel, Johannes: CRISPR/Cas9-mediated Cxcr3 gene knock-out in unstimulated murine primary CD4+T cells
P5.08
Lang-Meli, Julia; Denecke, Anna-Lena; Ehrenmann, Philipp; Alizei, Elahe Salimi; Kiraithe, Muthamia; Walker, Andreas; Jacobi, Felix; Gostick, Emma; Böttler, Tobias; Price, David; Timm, Jörg; Thimme, Robert; Hofmann, Maike; Neumann-Haefelin, Christoph: Skewed HBV-specific CD8+T cell repertoire in chronic versus acute-resolving HBV infection
P5.09
Bockmann, Jan-Hendrik; Allweiss, Lena; Volmari, Annika; Kohsar, Matin; Kah, Janine; Giersch, Katja; Volz, Tassilo; Lütgehetmann, Marc; Lohse, Ansgar Wilhelm; Wiesch, Julian zur; Dandri, Maura: Analysis of the CXCL9-11 mediating recruitment of CXCR3+CD4 T cells to HDV-infected livers
P5.10
Liebig, Laura; Lindberg, Eric Lars-Helge; Adami, Elenora; Lopez-Anguita, Natalia; Patone, Giannino; Laschtowitz, Alena; Steinmann, Silja; Xu, Yang; Sebode, Marcial; Gagliani, Nicola; Schwinge, Dorothee; Hübner, Norbert; Schramm, Christoph: Single-nuclei RNA-sequencing of human liver samples reveals heterogeneity and compositional changes of biliary epithelial cell subpopulations during the progression of primary sclerosing cholangitis
P5.11
Schröter, Paulina E.; Steppich, Katja S.; Bartsch, Yannic; Kraft, Anke; Cornberg, Markus: Cytotoxic CD16+γδ T Cells Are Associated with Virus Control in Chronic Hepatitis B Virus (HBV) Infection by Mediating Antibody-Dependent Cellular Cytotoxicity (ADCC)
P5.12
Pohl-Topcu, Junika; Georgieva, Alexandra; Monte, Enric Redondo; Deschler, Sebastian; Kager, Juliane; Erlacher, Sophia; Zink, Joseph; Weber, Julius; Pedde, Anna-Marie; Hirschberger, Anna; Laschinger, Melanie; Hartmann, Daniel; Böttcher, Jan P.; Hüser, Norbert; Schmid, Roland; Knolle, Percy; Böttcher, Katrin: Mucosal-associated invariant T (MAIT) cells possess direct anti-tumour potential, but are rendered dysfunctional within the tumour microenvironment in HCC
P5.13
Werner, Jill; Reinscheid, Matthias; Thimme, Robert; Hofmann, Maike; Böttler, Tobias: No evidence for viral escape mutations in immunodominant CD4 HCV-specific epitopes
P5.14
Fischer, Janett; Pfefferkorn, Maria; Gerhadt, Florian; Seltmann, Jonathan; Berg, Thomas; van Bömmel, Florian: Association of fibronectin serum levels with loss of hepatitis B surface antigen in patients with chronic hepatitis B during nucleos(t)ide analogue treatment
P5.15
Ehlting, Christian; Bartz, Jennifer; Wolf, Stephanie D.; Gaestel, Matthias; Clark, Andrew R.; Trilling, Mirko; Luedde, Tom; Bode, Johannes: Disrupting the intracellular MK2/3-TTP interaction reduces inflammation but preserves antiviral mechanisms in CMV infection
P5.16
Muungani, Lorraine Tendai; Schefczyk, Stefan; Liang, Yaojie; Lu, Mengji; Broering, Ruth: Important roles of HBe and HBs antigens in the evasion of endogenous innate immune responses in Hepatitis B Virus infection
P5.17
Allweiss, Lena; Volmari, Annika; Manuilov, Dmitry; Urban, Stephan; Wedemeyer, Heiner; Nieves, Wildaliz; Wallin, Jeffrey J.; Mercier, Renee-Claude; Lau, Audrey; Dandri, Maura: Bulevirtide in combination with pegylated interferon alfa-2a shows a sustained off-treatment response in the liver
P5.18
Gottwick, Cornelia; Averhoff, Pia; Krzikalla, Daria; Digigow, Reinaldo; Fleischer, Sabine; Lohse, Ansgar Wilhelm; Carambia, Antonella; Herkel, Johannes: Tolerance induction by liver sinusoidal endothelial cells is preserved in liver fibrosis
P5.19
Dudek, Michael; Knolle, Percy; Fackler, Jonas; Donakonda, Sainitin; Gagliani, Nicola; Xu, Yang; Schramm, Christoph: Molecular pathways defining human CD8 T cell auto-aggression in immune-mediated liver diseases
P5.20
Zink, Joseph; Deschler, Sebastian; Erlacher, Sophia; Pistrenko, Karyna; Schmid, Roland; Böttcher, Katrin; Protzer, Ulrike: Mucosal-associated invariant T (MAIT) cells are functionally impaired and metabolically altered in patients with chronic HBV infection
P5.21
Cornberg, Markus; Lampertico, Pietro; Aleman, Soo; Bogomolov, Pavel; Stepanova, Tatyana; Ciesek, Sandra; Berger, Annemarie; Manuilov, Dmitry; Li, Mingyang; Lau, Audrey; Da, Ben; Chee, Grace; Brunetto, Maurizia; Zeuzem, Stefan; Wedemeyer, Heiner: Improvement in liver histology is observed in most patients with chronic hepatitis delta after 48 weeks of bulevirtide monotherapy
P5.22
Souleiman, Roni; Freyer, Erich; Dey, Suparna; Niehaus, Christian; Maasoumy, Benjamin; Wedemeyer, Heiner; Kraft, Anke; Heinrich, Bernd; Cornberg, Markus: Granzyme profiles in CXCR6+PD-1+CD8+T cells differentiate acute and chronic hepatitis flares and may reflect intrahepatic immune imprints
P5.23
Baumgarten, Julia; Pistrenko, Karyna; Schmid, Kevin; Wiedemann, Gabriela; Schmid, Roland: Influence of the Chemerin signaling pathway on NK cell function and migration
P5.24
Wilhelm, Laura Muana; Stoehr, Albrecht; Buggisch, Peter; John, Christine; Link, Ralph; Klinker, Hartwig; Merle, Uta; Cornberg, Markus; Sarrazin, Christoph; Berg, Thomas; Wedemeyer, Heiner: Previous hepatitis B virus infection and the risk of liver-related complications in patients after HCV cure – Data on more than 6000 patients from the German Hepatitis C-Registry (DHC-R)
P5.25
Erlacher, Sophia; Xie, Zhe; Deschler, Sebastian; Zink, Joseph; Pistrenko, Karyna; Schmid, Roland; Protzer, Ulrike; Böttcher, Katrin: Mucosal-associated invariant T (MAIT) cells exert direct anti-viral effector function against HBV
P5.26
Hagen, Maximilian; Stettler, Frederik; Schmidt, Fabian; von Bülow, Verena; Roderfeld, Martin; Roeb, Elke: Metabolic reprogramming of HBsAg-positive hepatocytes after stimulation with Schistosoma mansoni egg antigens
P5.27
Jördens, Markus; Chung, Brian; Øgaard, Jonas; Karlsen, Tom; Luedde, Tom; Melum, Espen: Distinct gene pathways and cell types define peribiliary disease states in PSC
P5.28
Killer, Alexander; Hellendahl, Elisa; Gliga, Smaranda; Bode, Johannes; Walker, Andreas; Luebke, Nadine; Timm, Jörg; Luedde, Tom; Bock, Hans Henrich: High proportion of complicated treatment courses in patients with chronic hepatitis E infection: Men and older patients may have higher risk for viral relapse, real life data from single centre
P5.29
Pilz, Sabrina Melanie; Gunasekaran, Karthikeyan; Worthmann, Anna; Schramm, Christoph; Heeren, Jörg; Schwinge, Dorothee: Intrahepatic T cell responses modulate thermogenic adaptation in adipose tissues
P5.30
Schmidt, Fabian; von Bülow, Verena; Stettler, Frederik; Wirth, Victoria; Sölter, Ricarda; Schramm, Gabriele; Grevelding, Christoph Gero; Roderfeld, Martin; Roeb, Elke: Schistosoma mansoni egg-derived antigens stimulate metabolic activity in the liver and colon by engaging insulin-like growth factor-1 receptor signaling pathways
P5.31
Koop, Paul-Henry; Clusmann, Jan; Engel, Bastian; Schneider, Carolin Victoria; Schneider, Kai Markus: Multimodal characterization of autoimmune hepatitis morbidity and metabolic phenotype
P5.32
Wintersteller, Hannah; Bosch, Miriam; Donakonda, Sainitin; Gemünd, Ioanna; Fürst, Anna; Kosinska, Anna; Oz, Edanur Ates; Souleiman, Roni; Wurmser, Christine; Almeida, Gustavo; Cornberg, Markus; Zehn, Dietmar; Wohlleber, Dirk; Protzer, Ulrike; Knolle, Percy: Circulating CD8 T cells are sentinels for intrahepatic T cell responses during HBV infection
P5.33
Wan, Xueshuai; Wu, Wei; Liu, Yunpeng; Du, Shunda; Li, Wei; Quan, Dongmei; Zhang, Ke; Wisskirchen, Karin; Protzer, Ulrike; Zhou, Yuhong; Qu, Xiujuan Qu: First-in-human Clinical Results of a Novel HBV-specific TCR T Cell Therapy (SCG101) in Patients With HBV-related Hepatocellular Carcinoma (HCC)
P5.34
Jacob, Alice; Panetas, Ioannis; Spitzer, Jasper; Pahutan, Lance F.; Kierderof, Katrin; Prinz, Marco; Knolle, Percy; Schmidt, Susanne; Abdullah, Zeinab: Impaired liver regeneration in obesity is driven by IFNAR signaling in Kupffer cells
P5.35
Stettler, Frederik; Kaur, Surmeet; Glebe, Dieter; von Bülow, Verena; Grevelding, Christoph Gero; Roeb, Elke; Roderfeld, Martin: S. mansoni infection of HBsAg-transgenic mice elicits hepatocellular damage, hepatic decompensation and carcinogenesis
P5.36
Kosinska, Anna; Oz, Edanur Ates; Bunse, Till; Gültan, Merve; Singh, Swati; Miko, Susanne; Protzer, Ulrike: Silencing of HBV and PD-L1 synergistically enhances the efficacy of therapeutic vaccination in high-titer HBV carrier mice
P5.37
Heni, Carolin; Werner, Jill; Hofmann, Maike; Thimme, Robert; Böttler, Tobias: HBsAg-specific CD4 T cell response in HBV vaccinated individuals
P5.38
Lehmler, Max; Tiemann, Mareike; Sebode, Marcial; Lohse, Ansgar Wilhelm; Herkel, Johannes; Steinmann, Silja: T cell hyporesponsiveness distinguishes Autoimmune Hepatitis from Drug-Induced Liver Injury
P5.39
Suo, Yuan; Salié, Henrike; Godbole, Ira; Päth, Günter; Beck, Jürgen; Nkongolo, Shirin; Thimme, Robert; Mogler, Carolin; Bengsch, Bertram: Deconvoluting the spatial immune landscape in the Hepatitis B Virus infected human liver at single-cell resolution
P5.40
Lang, Karl; Lang, Judith; Gulbins, Erich; Lang, Philipp; Bohn, Patrick: Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
P5.41
Chen, Fuwang; Chen, Jiadao; Gao, Yudi; Xie, Zhe; Jin, Tao; Xie, Zhe; Wisskirchen, Karin; Zhang, Ke; Protzer, Ulrike: Generation and functional analysis of spacer-modified HBV-specific chimeric antigen receptors
P5.42
Haas, Victor; Dirksen, Philipp; Gottwick, Cornelia; Grafen, Vera; Mangler, Franziska; Middendorf, Lukas; Schwinge, Dorothee; Schramm, Christoph: Virulent Enterococcus faecalis from individuals with Primary Sclerosing Cholangitis crosses the intestinal barrier and induces liver inflammation in Mdr2 -/- mice
P5.43
Freyer, Erich; Romero, Daniel Brown; Finney, George; Mathur, Anandita; Cooper, Lucy; Kraft, Anke; Maini, Mala K; Cornberg, Markus; Pallett, Laura J.: Myeloid reprogramming of T cells: a mechanism to maintain peritoneal homeostasis
P5.44
Brum, Amanda; Stindt, Sabine; Ehlting, Christian; Luedde, Tom; Bode, Johannes: Hepatitis C virus alters hepatocyte’s response to interleukin-1 by modulation of IκBα-mediated signaling
P5.45
Jeske, Samuel; Wettengel, Jochen; Gegenfurtner, Florian; Fischer, Konrad; Moosmüller, Judith; Chakraborty, Anindita; Schnieke, Angelika; Ko, Chunkyu; Burwitz, Benjamin; Protzer, Ulrike: Identification of amino acids restricting HBV receptor function in porcine NTCP