DOI:
10.1055/s-00000084
Synthesis
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The synthetic approach to threo-2-amino-3-hydroxy esters possessing long alkyl chains was performed from chiral azomethine ylides by reaction of (5R)-5-phenylmorpholin-2-one with long-chain aldehydes. In the presence of a second equiv of aldehydes, the azomethine ylide can be trapped: Brome VA, Harwood LM, Osborn HM. I.
Can. J. Chem. 2006;
84: 1448
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