DOI:
10.1055/s-00000083
Synlett
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References
As an example, replacement of the chlorine atoms by hydrogens in the antibiotic vancomycin induces a decrease of the antibacterial activity of up to 70%, see: Harris CM. Kannan R. Kopecka H. Harris TM.
J. Am. Chem. Soc. 1985;
107: 6652
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