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DOI: 10.1055/a-0749-8947
Bildgebung in der Kornea mittels optischer Kohärenztomografie – historische Entwicklung und neueste technische Fortschritte
Cornea Imaging by Optical Coherence Tomography – Historical Aspects and Most Recent Technical DevelopmentsPublication History
eingereicht 13 August 2018
akzeptiert 19 September 2018
Publication Date:
19 December 2018 (online)
Zusammenfassung
Die optische Kohärenztomografie (OCT) hat seit ihrer Einführung für die retinale Bildgebung in den 90er-Jahren eine rasante Entwicklung genommen und die Ophthalmologie revolutioniert. Während sie zu Beginn nur zur Untersuchung der Retina zum Einsatz kam, wurden in der Zwischenzeit auch zahlreiche Systeme zur Beurteilung des vorderen Augenabschnitts entwickelt. Basierend auf der Detektion und Verarbeitung des vom Gewebe zurückreflektierten und gestreuten Lichts, eröffnete sie dem Ophthalmologen völlig neue Möglichkeiten zur Untersuchung der Strukturen des vorderen Augenabschnitts. Je nach technischer Umsetzung erlauben OCT-Systeme für den vorderen Augenabschnitt die präzise Vermessung einzelner Schichten der Kornea und des Kammerwinkels oder – in Form von ultrahoch auflösender OCT – die detailreiche Darstellung der Hornhautmorphologie mit nahezu histologischer Auflösung. Letztere könnte durch weitere technische Entwicklungen vor allem hinsichtlich der Erhöhung der Aufnahmegeschwindigkeit zu einem wesentlichen Werkzeug in der Differenzialdiagnose und Verlaufsbeobachtung verschiedenster Erkrankungen der Hornhaut werden, das auch neue Einsichten in die Pathophysiologie dieser Erkrankungen liefert.
Abstract
Since its introduction for retinal imaging in the early 1990s, optical coherence tomography (OCT) has undergone rapid development and has revolutionised ophthalmology. Although OCT was initially used mainly for the examination of the retina, numerous systems for the assessment of the anterior segment of the eye have now been developed. OCT is based on the detection and processing of the light back-scattered and back-reflected by the tissue, and provides completely new possibilities for the ophthalmologist to examine the structures of the anterior eye segment. Depending on the technical implementation, OCT systems for the anterior eye allow precise measurement of individual layers of the cornea and the chamber angle or – in the form of ultrahigh resolution OCT – the detailed visualisation of corneal morphology with near histological resolution. Through further technical developments, especially with respect to an increase in acquisition speeds, OCT has become an essential tool in the differential diagnosis and follow-up of various diseases of the cornea and might also provide new insights into their pathophysiology.
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