Walter Halangk (1950 – 2018)

Am 20.08.2018 verstarb nach zweieinhalbjähriger, schwerer Erkrankung Prof. Dr. Walter Halangk in Magdeburg.

• Literatur

• 1 Halangk W. et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000; 106: 773-781
• 2 Wartmann T. et al. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology 2010; 138: 726-737
• 3 Halangk W. et al. Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation. Am J Physiol Gastrointest Liver Physiol 2002; 282: G367-G374
• 4 Zhang H. et al. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest 2013; 123: 1019-1031
• 5 Sendler M. et al. Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut 2013; 62: 430-439
• 6 Diakopoulos KN. et al. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes. Gastroenterology 2015; 148: 626-638.e17
• 7 Witt H. et al. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet 2006; 38: 668-673