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Planta Med 2019; 85(08): 678-688
DOI: 10.1055/a-0895-5838
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Preventive Effects of Total Flavonoid C-Glycosides from Abrus mollis on Nonalcoholic Fatty Liver Disease through Activating the PPARα Signaling Pathway

Xiao-Long Hu   *
1   State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Ya-Jun Niu   *
1   State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Mi Chen
2   Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Jia-Hao Feng
1   State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Wei Shen
1   State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Zhen-Zhou Jiang
2   Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
,
Xiao-Qi Zhang
4   Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, Peopleʼs Republic of China
,
Wen-Cai Ye
4   Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, Peopleʼs Republic of China
,
Fei Xiong
3   State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing, Peopleʼs Republic of China
,
Hao Wang
1   State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 17 November 2018
revised 06 April 2019

accepted 10 April 2019

Publication Date:
26 April 2019 (online)

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Abstract

Abrus pulchellus subsp. mollis (Hance) Verdc. (Leguminosae) is a well-known edible plant usually added to soups and beverages. In this study, vicenin-2 (1), isoschaftoside (2), schaftoside (3), and their enrichment fraction, total flavonoid C-glycosides, derived from the extracts of A. mollis, were firstly found to prevent nonalcoholic fatty liver disease both in vitro and in vivo. In the in vitro study, total flavonoid C-glycosides decreased the lipid accumulation in oleic acid-treated HepG2 cells. The mechanisms of total flavonoid C-glycosides are involved in the regulation of peroxisome proliferator-activated receptor α and its downstream, and the reduction of proinflammatory cytokines. In high-fat diet-induced fatty liver rats, total flavonoid C-glycosides decreased the levels of glutamic-oxalacetic transaminease and glutamic-pyruvic transaminase, and decreased the lipid accumulation both in the liver and blood without affecting food intake. In addition, total flavonoid C-glycosides also increased the activities of the antioxidant enzyme system in vivo. In conclusion, total flavonoid C-glycosides are active components of A. mollis on nonalcoholic fatty liver disease, and can be used in functional food and supplements for nonalcoholic fatty liver disease prevention and treatment.

Key words

Nonalcoholic fatty liver disease - Abrus pulchellus subsp. mollis - total flavonoid C-glycosides - high-fat diet - PPARα

* These two authors made an equal contribution to this article.


 

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