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Horm Metab Res 2019; 51(08): 522-530
DOI: 10.1055/a-0923-9184
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

Jian Xu   *
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
,
Bin Wang   *
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
,
Qian Li
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
,
Qiuming Yao
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
,
Xi Jia
1   Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China
,
Ronghua Song
2   Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
,
Jin-an Zhang
2   Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
› Author Affiliations
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Publication History

received 13 May 2018

accepted 09 May 2019

Publication Date:
13 August 2019 (online)

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Abstract

The risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.

Key words

thyroid dysfunction - Hashimoto’s thyroiditis - gout - hyperuricemia - risk factors

* These two authors contributed equally to this work.


Supplementary Material

 

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