Safran – das pflanzliche Gold ist vielseitig nutzbar

Summary

Die Studienlage zur pharmakologischen Wirkung und klinischen Wirksamkeit bei Depressionen, Angststörungen, kognitiven Störungen, erektiler Dysfunktion, Diabetes und geringer bis mäßiger Makuladegenerationist, wenn nicht plausibel, zumindest vielversprechend.

Keywords

Heilpflanze - Safran - Crocussativus - Heilpflanzenporträt

Publication History

Article published online:
16 December 2020

• Literatur

• 1 Asbaghi O, Soltani S, Norouzi N, Milajerdi A, Choobkar S, Asemi Z. The effect of saffron supplementation on blood glucose and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2019; 47: 102158
• 2 Ashktorab H, Soleimani A, Singh G, Amr A, Tabtabaei S, Latella G, Stein U, Akhondzadeh S, Solanki N, Gondré-Lewis MC, Habtezion A, Brim H. Saffron: The golden spice with therapeutic properties on digestive diseases. Nutrients 2019; 11: 943
• 3 Avgerinos KI, Vrysis C, Chaitidis N, Kolotsiou K, Myserlis PG, Kapogiannis D. Effects of saffron (Crocus sativus L.) on cognitive function. A systematic review of RCTs. Neurol Sci 2020 May 23
• 4 Berger F, Hensel A, Nieber K. Neuroscience. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience 2011; 180: 238-47
• 5 Blaschek W, Hilgenfeldt U, Holzgrabe U, Mörike K, Reichling J, Ruth J. HagerROM 2016. Hagers Enzyklopädie der Arzneistoffe und Drogen. Berlin Heidelberg: Springer-Verlag; 2016
• 6 Bukhari SI, Manzoor M, Dhar MK. A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids. Biomed Pharmacother 2018; 98: 733-745
• 7 Ceremuga TE, Ayala MP, Chicoine CRW, Chun CSM, DeGroot CJM, Henson DT, Randall CSA, Stanley CLR, Beaumont CDM. Investigation of the anxiolytic and antidepressant effects of crocin, a compound from saffron (Crocus sativus L), in the male Sprague-Dawley rat. AANA J 2018; 86: 225-233
• 8 Dai L, Chen L, Wang W. Safety and efficacy of saffron (Crocus sativus L.) for treating mild to moderate depression: A systematic review and meta-analysis. J Nerv Ment Dis 2020 Jan 7
• 9 De Monte C, Carradori S, Chimenti P, Secci D, Mannina L, Alcaro F, Petzer A, N’Da CI, Gidaro MC, Costa G, Alcaro S, Petzer JP. New insights into the biological properties of Crocus sativus L.: Chemical modifications, human monoamine oxidases inhibition and molecular modeling studies. Eur J Med Chem 2014; 82: 164-71
• 10 Ghaderi A, Asbaghi O, Reiner Ž, Kolahdooz F, Amirani E, Mirzaei H, Banafshe HR, Maleki Dana P, Asemi Z. The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complement Ther Med 2020; 48: 102250
• 11 Heitmar R, Brown J, Kyrou I. Saffron (Crocus sativus L.) in ocular diseases: A narrative review of the existing evidence from clinical ctudies. Nutrients 2019; 11 (03) 649
• 12 Khaksarian M, Behzadifar M, Behzadifar M, Alipour M, Jahanpanah F, Re TS, Firenzuoli F, Zerbetto R, Bragazzi NL. The efficacy of Crocus sativus (saffron) versus placebo and Fluoxetine in treating depression: A systematic review and meta-analysis. Psychol Res Behav Manag 2019; 12: 297-305
• 13 Lechtenberg M, Hensel A. Safran gegen Depressionen. Dtsch Apothekerzeitung 2016; 156: 46-8
• 14 Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: A systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol 2014; 29: 517-27
• 15 Maleki-Saghooni N, Mirzaeii K, Hosseinzadeh H, Sadeghi R, Irani M. A systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters. Avicenna J Phytomed 2018; 8: 198-209
• 16 Marx W, Lane M, Rocks T, Ruusunen A, Loughman A, Lopresti A, Marshall S, Berk M, Jacka F, Dean OM. Effect of saffron supplementation on symptoms of depression and anxiety: A systematic review and meta-analysis. Nutr Rev 2019: nuz023
• 17 Pourmasoumi M, Hadi A, Najafgholizadeh A, Kafeshani M, Sahebkar A. Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis. Pharmacol Res 2019; 139: 348-359
• 18 Rahmani J, Manzari N, Thompson J, Clark CCT, Villanueva G, Varkaneh HK, Mirmiran P. The effect of saffron on weight and lipid profile: A systematic review, meta-analysis, and dose-response of randomized clinical trials. Phytother Res 2019; 33: 2244-2255
• 19 Rahmani J, Bazmi E, Clark C, Hashemi Nazari SS. The effect of saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020; 49: 102298
• 20 Ranjbar H, Ashrafizaveh A. Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis. Avicenna J Phytomed 2019; 9: 419-427
• 21 Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord 2018; 227: 330-337
• 22 Tóth B, Hegyi P, Lantos T, Szakács Z, Kerémi B, Varga G, Tenk J, Pétervári E, Balaskó M, Rumbus Z, Rumbus Z, Rakonczay Z, Bálint ER, Kiss T, Csupor D. The efficacy of saffron in the treatment of mild to moderate depression: A meta-analysis. Planta Med 2019; 85: 24-31