Recent Advances in the Synthesis of Heterocycles by the Aza-Wittig Reaction

Abstract

The formation of the C=N bond in recent studies on heterocyclic compounds via the aza-Wittig reaction is reviewed. Furthermore, two different strategies for the formation of heterocyclic compounds, including intermolecular and intramolecular aza-Wittig reactions are described. The primary aim of this review is to provide up-to-date information on the application of the aza-Wittig reaction in the synthesis of a wide range of N-containing heterocyclic compounds in the chemical literature since 2010.

1 Introduction

2 Mechanism of the Staudinger and Aza-Wittig Reactions

3 Intramolecular Aza-Wittig Reaction

4 Intermolecular Aza-Wittig Reaction

5 Conclusion

Key words

aza-Wittig reaction - iminophosphorane - N-containing heterocycles - Staudinger reaction - cyclization

Publication History

Received: 13 December 2020

Accepted after revision: 18 February 2021

Accepted Manuscript online:
18 February 2021

Article published online:
29 April 2021

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