Transkranielle Gleichstromstimulation und Sertralin zur Behandlung der Zwangsstörung

ZUSAMMENFASSUNG

Zwangsgedanken und -handlungen sind für Betroffene meist quälend und können mit einer hohen Beeinträchtigung des sozialen und beruflichen Funktionsniveaus verbunden sein. Wir berichten von einer 30-jährigen Patientin mit bislang therapieresistenter Zwangsstörung, die mit transkranieller Gleichstromstimulation als Zusatzverfahren zur Medikation und Psychotherapie behandelt wurde. Zum Einsatz kam dabei eine für die Depressionsbehandlung typische Elektrodenplatzierung über beiden dorsolateralen präfrontalen Kortizes. Nach einer 3-wöchigen Behandlung mit 15 Stimulationen wurde eine deutliche Reduktion der Zwangssymptomatik erreicht, die auch 3 Wochen nach der Behandlung noch anhielt. Neue Therapieverfahren aus dem Bereich der nicht invasiven Hirnstimulation, wie die transkranielle Gleichstromstimulation, könnten bei therapieresistenter Zwangserkrankung einen potenziellen Behandlungsansatz darstellen.

ABSTRACT

Obsessive-compulsive symptoms are usually distressing for those affected and can be associated with a high level of impairment in social and occupational functioning. We report the use of transcranial direct current stimulation in a 30-year-old female patient with treatment-resistant obsessive-compulsive disorder. During her inpatient stay, transcranial direct current stimulation was applied as an add-on to medication and psychotherapy. Electrodes were placed over both dorsolateral prefrontal cortices, which is the typical montage for depression treatment. After 3 weeks of treatment (15 stimulations), a significant reduction of obsessive-compulsive symptoms was found, persisting 3 weeks after treatment. New therapeutic methods in the field of non-invasive brain stimulation, such as transcranial direct current stimulation, could develop as a potential treatment approach for treatment-resistant obsessive-compulsive disorder.

Schlüsselwörter

Zwang - tDCS - nicht invasive Hirnstimulation - Neuromodulation

Key words

Obsession - compulsion - OCD - non-invasive brain stimulation - neuromodulation

Publication History

Article published online:
02 November 2021

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