Towards Rare-Functionalized N-Alkenyl-1H-pyrroles via Regioselectively Metalated N-Isopropenyl-1H-pyrroles

Abstract

Deprotonative metalation of N-isopropenyl-1H-pyrroles with superbases followed by trapping with a variety of electrophiles was studied as an effective tool for the regioselective functionalization of 1H-pyrroles.

Key words

N-isopropenyl-1H-pyrrole - N-isopropenyl-4,5,6,7-tetra­hydro-1H-indole - superbases - metalation - functionalization

Publication History

Received: 18 November 2021

Accepted after revision: 11 January 2022

Accepted Manuscript online:
11 January 2022

Article published online:
01 March 2022

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