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Endo-Praxis 2022; 38(03): 129-133
DOI: 10.1055/a-1776-2809
Originalarbeit

Covid-19: Auswirkungen auf den Gastrointestinaltrakt

Martin Sperrer
1   Klinik für Innere Medizin I, Schwerpunkt Gastroenterologie, Sana Klinikum Lichtenberg, Berlin
,
Hendrik Buchholz
1   Klinik für Innere Medizin I, Schwerpunkt Gastroenterologie, Sana Klinikum Lichtenberg, Berlin
,
Gudrun Rettig
1   Klinik für Innere Medizin I, Schwerpunkt Gastroenterologie, Sana Klinikum Lichtenberg, Berlin
,
Siegbert Faiss
1   Klinik für Innere Medizin I, Schwerpunkt Gastroenterologie, Sana Klinikum Lichtenberg, Berlin
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Zusammenfassung

Im Zeitalter der Omikronwellen hat sich das Pandemiegeschehen noch einmal gewandelt. Die größte Hürde waren im Gegensatz zu den ersten Wellen nicht die vielen schwerstkranken Patienten, sondern die Personalausfälle durch die Infektionen. Die schweren Verläufe sind trotz der hohen Infektionszahlen im Januar bis März weitestgehend von den Intensivstationen ferngeblieben. Unter den niedrigen Infektionszahlen ist ein Durchatmen, ein persönlicher Austausch bei Kongressen und fast vorpandemisches Arbeiten wieder möglich. In Hinblick auf erneute Wellen besteht die Herausforderung darin ein Umfeld zu schaffen, dass gastroenterologische Behandlung und Diagnostik im benötigten Umfang gewährleisten kann ohne dabei Personal oder Patient:innen zu gefährden. Dazu ist eine konsequente Strategie aus Testung, gesteigerten Hygieneschutzmaßnahmen und nicht zuletzt Immunisierung notwendig.

Schlüsselwörter

Pandemie - SARS-CoV-2 - gastrointestinale Symptome


Publication History

Article published online:
12 September 2022

© 2022. Thieme. All rights reserved.

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  • Literatur

  • 1 Schilling J, Lehfeld AS, Schumacher D. et al. Krankheitsschwere der ersten COVID-19-Welle in Deutschland basierend auf den Meldungen gemäß Infektionsschutzgesetz. Journal of Health Monitoring, 5(S11) 2020; 2-20
    Google Scholar
  • 2 Redd WD, Zhou JC, Hathorn KE. et al. Prevalence and Characteristics of Gastrointestinal Symptoms in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study. Gastroenterology, August 2020; 765-767
    CrossrefPubMedGoogle Scholar
  • 3 Pan L, Mu M, Yang P. et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive Cross-Sectional, Multicenter Study. The American journal of gastroenterology, 14. April 2020; 115: 766-773
    CrossrefPubMedGoogle Scholar
  • 4 Sultan Shahnaz. et al. AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19. Gastroenterology, July 2020; 320-334.e27
    CrossrefPubMedGoogle Scholar
  • 5 Sharma A, Ahmad Farouk. , I., & Lal, S. K. COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Viruses, 29. Januar 2021; 13: 202
    Google Scholar
  • 6 Shang J, Ye G, Shi K. et al. Structural basis of receptor recognition by SARS-CoV-2. Nature, 30. März 2020; 581: 221-224
    CrossrefPubMedGoogle Scholar
  • 7 Kumar A, Faiq MA, Pareek V. et al. Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients. Medical hypotheses, November 2020; 144: 110271
    CrossrefPubMedGoogle Scholar
  • 8 Bröer S, Fairweather SJ.. Amino Acid Transport Across the Mammalian Intestine. Comprehensive Physiology, 13. Dezember 2018; 9: 343-373
    CrossrefPubMedGoogle Scholar
  • 9 Hashimoto T, Perlot T, Rehman A. et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature, 25. Juli 2012; 487: 477-481
    CrossrefPubMedGoogle Scholar
  • 10 Potdar AA, Dube S, Naito T. et al. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. Gastroenterology, Februar 2021; 160: 809-822.e7
    CrossrefPubMedGoogle Scholar
  • 11 Chin AWH, Chu JTS, Perera MRA. et al. Stability of SARS-CoV-2 in different environmental conditions. The Lancet Microbe, Mai 2020; 1: e10
    CrossrefPubMedGoogle Scholar
  • 12 Das S, Jayaratne R, Barrett KE.. The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea. Cellular and molecular gastroenterology and hepatology, 5. März 2018; 6: 33-45
    CrossrefPubMedGoogle Scholar
  • 13 Hoffmann M, Kleine-Weber H, Schroeder S. et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 16. April 2020; 181: 271-280.e8
    Google Scholar
  • 14 Bertram S, Heurich A, Lavender H. et al. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS One 2012; 7: e35876
    CrossrefPubMedGoogle Scholar
  • 15 Singh AK, Jena A, Kumar MP. et al. Risk and outcomes of coronavirus disease in patients with inflammatory bowel disease: A systematic review and meta-analysis. United European gastroenterology journal, März 2021; 9: 159-176
    CrossrefPubMedGoogle Scholar
  • 16 Tripathi K, Godoy Brewer G, Thu Nguyen M. et al. COVID-19 and Outcomes in Patients With Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Inflammatory bowel diseases, 27. Oktober 2021; izab236
    Google Scholar
  • 17 Müller JA, Groß R, Conzelmann C. et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism, Februar 2021; 3: 149-165
    CrossrefPubMedGoogle Scholar
  • 18 Samanta J, Gupta R, Singh MP. Coronavirus disease 2019 and the pancreas. Pancreatology: official journal of the International Association of Pancreatology (IAP), Dezember 2020; 20: 1567-1575
    CrossrefPubMedGoogle Scholar
  • 19 Guan WJ, Liang WH, Zhao Y. et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. The European respiratory journal, Mai 2020; 55: 2000547
    CrossrefPubMedGoogle Scholar
  • 20 Hussain A, Bhowmik B, do Vale Moreira NC.. COVID-19 and diabetes: Knowledge in progress. Diabetes Res Clin Pract., April 2020; 162: 108142
    CrossrefPubMedGoogle Scholar
  • 21 Jothimani D, Venugopal R, Abedin MF. et al. COVID-19 and the liver. Journal of hepatology, November 2020; 73: 1231-1240
    CrossrefPubMedGoogle Scholar
  • 22 Jothimani D, Venugopal R, Abedin MF. et al. COVID-19 and the liver. Journal of hepatology, November 2020; 73: 1231-1240
    CrossrefPubMedGoogle Scholar
  • 23 Zeng W, Qi K, Ye M. et al. Gastrointestinal symptoms are associated with severity of coronavirus disease 2019: a systematic review and meta-analysis. European journal of gastroenterology & hepatology, Februar 2022; 34: 168-176
    CrossrefPubMedGoogle Scholar
  • 24 Chen Y, Chen L, Deng Q. et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. Journal of medical virology 2020; 92: 833-840
    CrossrefPubMedGoogle Scholar
  • 25 Jones DL, Baluja MQ, Graham DW. et al. Shedding of SARS-CoV-2 in feces and urine and its potential role in person-to-person transmission and the environment-based spread of COVID-19. The Science of the total environment, 20. Dezember 2020; 749: 141364
    CrossrefPubMedGoogle Scholar
  • 26 Rubio-Acero R, Beyerl J, Muenchhoff M. et al. Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience. The Science of the total environment, 25. November 2021; 797: 149031
    CrossrefPubMedGoogle Scholar
  • 27 Peinado B, Martínez-García L, Martínez F. et al. Improved methods for the detection and quantification of SARS-CoV-2 RNA in wastewater. Scientific reports.“ Scientific reports, 3. Mai 2022; 12: 7201
    CrossrefPubMedGoogle Scholar
  • 28 Kitajima M, Ahmed W, Bibby K. et al. SARS-CoV-2 in wastewater: State of the knowledge and research needs. The Science of the total environment, 15. Oktober 2020; 739: 139076
    CrossrefPubMedGoogle Scholar
  • 29 Frieling T.. Consequences of the COVID-19/SARS-CoV-2 pandemic for gastroenterology in Germany. Der Gastroenterologe: Zeitschrift fur Gastroenterologie und Hepatologie. 2020; 15: 498-505
    CrossrefPubMedGoogle Scholar
  • 30 Gralnek IM, Hassan C, Beilenhoff U. et al. ESGE and ESGENA Position Statement on gastrointestinal endoscopy and the COVID-19 pandemic. Endoscopy 2020; 52: 483-490
    Article in Thieme ConnectPubMedGoogle Scholar
  • 31 Sud A, Jones ME, Broggio J. et al. Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic. Annals of oncology: official journal of the European Society for Medical Oncology., August 2020; 31: 1065-1074
    CrossrefPubMedGoogle Scholar