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Synlett 2022; 33(11): 1011-1016
DOI: 10.1055/a-1787-1159
DOI: 10.1055/a-1787-1159
synpacts
The Conceptual Development of a Conjunctive Olefination
We thank the Engineering and Physical Sciences Research Council (EPSRC, New Investigator Award, Grant Number EP/V006401/1 to M.S.) for funding. M.S. thanks the University of Nottingham and the Green Chemicals Beacon of Excellence for a Nottingham Research Fellowship. D.F. thanks the School of Chemistry, University of Nottingham, for a doctoral fellowship.
Abstract
We recently discovered a functional group tolerant and transition-metal-free conjunctive olefination reaction with applications in late-stage functionalization chemistry. In this Synpacts contribution, we analyze the conceptual background that has stimulated the discovery of this reactivity and reflect on the key aspects of its development.
1 Introduction
2 Conceptual Background
2.1 Photoredox-Mediated Giese Reaction
2.2 Photoredox Radical-Polar Reactivity
3 The Development of the Process
4 Conclusion
Key words
photoredox catalysis - Wittig reaction - radical-polar crossover - conjunctive olefination - radical chemistryPublication History
Received: 24 February 2022
Accepted after revision: 03 March 2022
Accepted Manuscript online:
03 March 2022
Article published online:
01 April 2022
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