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Synthesis 2022; 54(21): 4673-4682
DOI: 10.1055/a-1829-0262
DOI: 10.1055/a-1829-0262
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Catalyst-Controlled Chemodivergent [3+3] and [3+2] Formal Cycloadditions of Azomethine Ylides with Diphenylcyclopropenone
We thank the Ministerio de Ciencia e Innovación (MICINN) and Fondo Europeo de Desarrollo Regional (FEDER, UE) for financial support (Agencia Estatal de Investigación/Project PGC2018-098660-B-100). J. C. thanks the Ministerio de Educación Cultura y Deportes for a FPU fellowship. A. P. thanks the MICINN for a predoctoral fellowship.
Dedicated to Prof. Joan Bosch on the occasion of his retirement
Abstract
Chemodivergent cycloadditions of azomethine ylides with diphenylcyclopropenone involving either Cu-catalyzed [3+3] or Ag-catalyzed [3+2] processes have been developed. These transformations provide a highly efficient method for the preparation of a variety of aromatic substituted dihydropyridinones and dihydropyrrolones with excellent regio and diasteroselectivities.
Key words
chemodivergent reactions - [3+3] and [3+2] cycloadditions - azomethine ylide - cyclopropenoneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1829-0262.
- Supporting Information
Publication History
Received: 28 March 2022
Accepted after revision: 19 April 2022
Accepted Manuscript online:
19 April 2022
Article published online:
09 June 2022
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