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Synfacts 2009(2): 0224-0224  
DOI: 10.1055/s-0028-1087624
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 1,3-Dinitroalkanes with Immobilized Amines

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
K. Motokura, M. Tada, Y. Iwasawa*
The University of Tokyo, Japan
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Publication History

Publication Date:
22 January 2009 (online)

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Significance

Primary and tertiary amines were immobilized on the surface of the silica-alumina (SA) support by silane-coupling reactions to give the silica-alumina-supported double-amine catalyst (SA-NH2-NEt2). The reaction of arylaldehydes 1 and nitromethane was carried out with SA-NH2-NEt2 to give the corresponding 1,3-dinitro­alkanes 2 in 48-93% yield (11 examples).