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Horm Metab Res 1977; 9(6): 489-491
DOI: 10.1055/s-0028-1093506
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© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Acute Hypercalcemia on the Level of Plasma Growth Hormone during Oral Glucose Tolerance Test

Y.  Gilboa , A.  Brauman , T.  Rosenberg , I.  Hertzeanu
  • Department of Medicine "8" and the Endocrine Unit, Assaf Harofeh Hospital, Zerifin and the University of Tel-Aviv Medical School, Israel
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Publication Date:
23 December 2008 (online)

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Abstract

It has been recently shown that acute hypercalcemia increases the release of growth hormone in man. We investigated the effect of intra-venous administration of calcium gluconate on the levels of growth hormone, during OGTT, in 8 non-obese subjects.

When an OGTT was performed with the addition of i.v. normal saline, no significant increase of serum growth hormone concentration was seen.

However i.v. administration of calcium gluconate with OGTT induced a significant increase of growth hormone at 120 and 180 minutes (from 1.4 ± 0.8 ng/ml to 13.4 ± 5.7 ng/ml and 9.3 ± 2.1 ng/ml respectively).

The growth hormone response to acute hypercalcemia was not abolished by a simultaneous OGTT, showing that the stimulatory effect of high levels of plasma calcium overcomes the inhibitory action of glucose.

Key words

Oral Glucose Tolerance Test (OGTT) - Hypercalcemia - Growth Hormone (GH)

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