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Horm Metab Res 1976; 8(6): 455-458
DOI: 10.1055/s-0028-1093594
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© Georg Thieme Verlag KG Stuttgart · New York

Experimental Hypergastrinaemia in the Dog

H. M. Jennewein , P. C. Ganguli , R.  Siewert , F.  Waldeck
  • Pharmaforschung Biologie, C.H. Boehringer Sohn, Ingelheim/Rhein, Germany
    University Department of Surgery, Manchester Royal Infirmary, U.K.
    Klinik und Poliklinik für Allgemein-Chirurgie der Universitätsklinik Göttingen, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

In order to investigate chronic hypergastrinaemia in dogs, studies with various excluded antrum preparations were performed. Gastric secretion was collected from denervated fundic pouches and gastrin levels were measured pre- and postoperatively by radioimmunoassay. In some samples the gastrins were separated according to their molecular size.

Distinct hypergastrinaemia and acid hypersecretion developed in dogs where the antrum was excluded by a mucosal septum. Gastrin levels rose to 349 ±64 pg/ml (normal 76 ± 19 pg/ml). Analysis of the gastrin pattern showed a predominance of smaller gastrin components. Although there was marked hypersecretion in most of the dogs with hypergastrinaemia, no close correlation was evident between these parameters. Some of the dogs with hypergastrinaemia developed anastomotic ulcers.

Key words

Experimental Hypergastrinaemia - Acid Secretion - Gastrin Components - Experimental Ulcers

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