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Horm Metab Res 1976; 8(3): 215-217
DOI: 10.1055/s-0028-1093643
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© Georg Thieme Verlag KG Stuttgart · New York

Decreased Pituitary Growth Hormone Content in Rats Treated Neonatally with High Doses of L-Thyroxine[*]

A. M. Pascual-Leone1 , M. D. Garcia2 , F.  Hervás2 , G. Morreale de Escobar2
  • 1Departamento de Bioquímica del C.S.I.C., Facultad de Farmacia de la Universidad Complutense, Madrid, and
  • 2Departamento de Endocrinología Experimental, Instituto G. Marañón, C.S.I.C, Centro de Investigaciones Biológicas, Velázquez 144, Madrid, Spain
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Growth hormone and thyrotrophic hormone content have been measured by specific radioimmunoassays in anterior pituitaries of 22 day old rats. These animals were injected with saline or very high doses of L-thyroxine during the neonatal period in order to induce the "neo-T4" syndrome. Growth of such animals is known to be affected. It was found that not only TSH but also GH content of the T4-treated animals was significantly lower than that of the saline-injected controls.

Key words

Thyroxine - Neonatal-T4 Syndrome - Rats - TSH - GH

1 This work was supported by funds from the "Fundacion Rodriguez-Pascual", and the "Fondo Nacional para el DesarroIlo de la Investigacion Cientifica", of Spain.

1 This work was supported by funds from the "Fundacion Rodriguez-Pascual", and the "Fondo Nacional para el DesarroIlo de la Investigacion Cientifica", of Spain.

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