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Horm Metab Res 1974; 6(6): 522-524
DOI: 10.1055/s-0028-1093802
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of the Antiestrogen Nafoxidine on the Occurrence of Estrogen-Dependent Renal Tumors in Hamster

P.  Antonio , M.  Gabaldón , T.  Lacomba , A.  Juan
  • Servicio Cancerología Experimental, Facultad Medicina, Paseo al Mar, Valencia, Spain
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Chronic treatment with diethylstilbestrol (DES) and polydiethylstilbestrol phosphate produces renal tumors in male hamsters. The antiestrogen nafoxidine administered simultaneously with DES completely inhibits tumor formation. Hepatic glucuronyltransferase activity towards DES decreases in hamsters treated chronically with DES; in hamsters treated with DES and nafoxidine the activity is not modified. The presence of renal tumor results in an increase of activity.

Key words

Diethylstilbestrol - Polydiethylstilbestrol Phosphate - Nafoxidine - Renal Tumors - Glucuronyltransferase

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