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Horm Metab Res 1974; 6(3): 173-175
DOI: 10.1055/s-0028-1093865
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© Georg Thieme Verlag KG Stuttgart · New York

Glucose Intolerance and Islet Damage in Mice Immunized with Homologous Endocrine Pancreas - A Preliminary Communication

J.  Nerup1 , O. Ortved Andersen1 , G.  Bendixen2 , J.  Egeberg3 , R.  Gunnarsson4 , H.  Kromann1 , J. E. Poulsen5
  • 1Medical Department E, Frederiksberg Hospital, Copenhagen, Denmark
  • 2Medical Department TA, Rigshospitalet, Copenhagen, Denmark
  • 3Department of Anatomy, University of Copenhagen, Denmark
  • 4Department of Histology, University of Uppsala, Sweden
  • 5Steno Memorial Hospital, Gentofte, Denmark
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Mice developed degenerative changes of B-cells with loss of insulin granules, extravascularly situated mononuclear cell infiltration of the islets of Langerhans, and glucose intolerance eight and fifteen days after immunization with homologous islets in complete Freund's adjuvant. Murine insulin and adjuvants in comparable preparations did not cause similar changes. The condition was transient, but has the following features in common with juvenile diabetes mellitus in man: glucose intolerance, mononuclear cell infiltration of the islets and organ specific, anti-pancreatic cellular hypersensitivity. It may therefore serve as a useful model in diabetes research.

Key words

Experimental Diabetes - Insulitis - Autoimmunity

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