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Horm Metab Res 1974; 6(3): 175-177
DOI: 10.1055/s-0028-1093866
DOI: 10.1055/s-0028-1093866
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Antigenicity of Monocomponent Porcine Insulin in Rabbits
Further Information
Publication History
Publication Date:
08 January 2009 (online)
Abstract
Monocomponent and commercial porcine insulin preparations administered with Freund's adjuvant, induced insulin antibodies in rabbits. The results show that the proinsulin-like contaminants in commercial insulin are not the essential stimuli for insulin antibody formation, and that purification of insulin per se is not sufficient to render insulin non-immunogenic. The physical state of insulin is more important in its immunogenicity.
Key words
Monocomponent Insulin - Insulin Antibodies