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Horm Metab Res 1974; 6(2): 146-150
DOI: 10.1055/s-0028-1093880
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© Georg Thieme Verlag KG Stuttgart · New York

Protein Kinase in Adipose Tissue: Effect of Hypophysectomy

E.  Gorin [*] , H. M. Goodman
  • Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Hypophysectomy was found to decrease the cAMP-dependent and independent protein kinase activity in adipose tissue and isolated adipocytes, as observed with protamine or histone substrates. Hypophysectomy did not affect the sensitivity of protein kinase to cAMP at various nucleotide concentrations. Adipose tissue was shown to contain a considerable phosphoprotamine phosphatase activity which was not affected by hypophysectomy. The data presented suggest that the decreased protein kinase activity may be, at least partly, responsible for the decreased cAMP-induced activation of lipase in adipose tissue of hypophysectomized rats.

Key words

Protein Kinase - Adipose Tissue - Hypophysectomy

1 Present address: Department of Biochemistry, Hebrew University - Hadassah Medical School, Jerusalem, Israel

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