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Horm Metab Res 1974; 6(1): 40-44
DOI: 10.1055/s-0028-1093901
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© Georg Thieme Verlag KG Stuttgart · New York

Glycogen Synthetase and Phosphorylase Activities in Different Tissues of Genetically Obese Mice

I.  Das [*] , D. A. Hems
  • Department of Biochemistry, Imperial College of Science and Technology, London SW 7, England
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

Glycogen synthetase and phosphorylase were studied in different tissues of lean and genetically obese (ob/ob) mice. An increase in liver and heart phosphorylase was observed in obese mice compared to lean mice. Ileum phosphorylase was also increased in older obese mice. Glycogen synthetase activities in obese mice tissues were not very different from those in lean mice; in younger animals skeletal muscle glycogen synthetase was higher in obese mice, but this difference was reversed in older mice. After three weeks treatment with hyperbaric oxygen, the phosphorylase activity of lean mice was increased in several tissues compared to control values, thus diminishing the differences in this enzyme between lean and obese mice.

Key words

Obese - Hyperglycemic Mice - Glycogen Synthetase - Phosphorylase - Insulin Resistance - Hyperbaric Oxygen

1 Present address: Dept. of Exptl. Pathology, Cardiothoracic Institute, London 5 W 3 6HP, England.

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