Isolation and Pharmacological Action of Epistephanine, an Alkaloid of Stephania hernandifolia

A. B. Ray; S. Chattopadhyay; R. M. Tripathi; S. S. Gambhir; P. K. Das

doi:10.1055/s-0028-1097199

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Planta Med 1979; 35(2): 167-173
DOI: 10.1055/s-0028-1097199

Research Articles

Isolation and Pharmacological Action of Epistephanine, an Alkaloid of Stephania hernandifolia

A. B. Ray¹ , S. Chattopadhyay¹ , R. M. Tripathi² , S. S. Gambhir² , P. K. Das²

¹Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
²Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

Alkaloids epistephanine, hernandifoline, aknadinine and magnoflorine have been isolated from the aerial parts of Stephania hernandifolia (Willd.) Walp. This is the first report of the occurrence of epistephanine in S. hernandifolia and it appears to be identical with aknadine, an uncharacterised alkaloid of this plant previously reported by an Indian worker. Epistephanine was found to possess significant adrenergic neurone blocking activity.

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