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Planta Med 1979; 35(4): 370-372
DOI: 10.1055/s-0028-1097232
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Effect of Embelia ribes on Uterine Weight of Normal and Ovariectomized Rats

A. O. Prakash1
  • School of Studies in Zoology, Jiwaji University, Gwalior, 474002, India.
1 Present address: Division of Endocrinology, Central Drug Research Institute, Lucknow 226001, India.
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

Total 50 % ethanolic and benzene extracts of Embelia ribes Burm. (dried berries) have been investigated for their oestrogenic activity in bilaterally ovariectomized immature female albino rats. Both extracts exhibited oestrogenic activity, which is dose dependent. Both extracts caused, a significant increase in the oestrone induced gain in uterine weight of immature rats when administered at a dose of 75 mg/kg (vs. Control P < 0.01 and < 0.05). In doses of 300 mg/kg the benzene extract was toxic. Of the two extracts, 50 % ethanolic extract was more potent. Interestingly, the activity is more pronounced at lower rather than at higher doses.

Key Word Index

Embelia ribes - Myrsinaceae - Oestrogenic Activity - Immature Rats

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