Zur Behandlung der peripheren Arteriosklerose

Zusammenfassung

Das Theobromin-Magnesium-Oleat (Keeser) wurde 6 bis 8 Wochen Patienten, die an peripheren sklerotischen Durchblutungsstörungen litten, in einer Dosierung von dreimal täglich 2 Tabletten gegeben. Durch einen Vergleich des Oszillogramms vor und nach dieser Therapie konnte bei 45 Kranken eine deutliche Besserung des Funktionszustandes der großen Arterien an den unteren Extremitäten festgestellt werden. Das Resultat deutet darauf hin, daß die günstigen Ergebnisse wenigstens zum Teil auf eine Beeinflussung der Gefäßveränderungen und nicht nur auf eine Förderung kollateraler Bahnen zurückzuführen sind.

Summary

The report is based on studies in 64 patients with marked arteriosclerotic disturbances of peripheral blood flow, which had caused intermittent claudication. Oscillometry, before and after treatment, was used to measure the effectiveness of medication. The advantages and limitation of this method of assessment are briefly discussed. Theobromine-magnesium oleate was given by mouth for 6—8 weeks, 0.2 to 0.4 Gm. daily. All patients had been followed for some time, but no other treatment was given during the test period.

Results:— In 45 patients there was definite improvement in the oscillogram. In 3, obvious deterioration was noted, while in 16 there was no significant change. Of the 45 with oscillographic improvement, 3 had no subjective change, but the others reported better walking performance and improved general well-being. Individual tests have not continued long enough for conclusive results. The majority of patients, however, are continuing treatment with brief interruptions and occasional addition of other drugs. Preliminary results suggest that adding sympatholytic drugs gives still better results. Purely endarteritic circulatory disturbances were not significantly influenced by the drug. It is doubtful, whether it has enough effect to save an extremity showing far advanced circulatory disorders.

Resumen

Acerca del tratamiento de la arterioesclerosis periférica: Sobre la influencia de la medicación con teobromina-oleato de magnesio sobre el oscilograma de las extremidades

El autor administró teobromina-oleato de magnesio (Keeser) durante 6—8 semanas a pacientes afectos de transtornos escleróticos del riego sanguíneo periférico a una dosis de 2 comprimidos, repetidos tres veces al día. Pudo comprobar, comparando el oscilograma obtenido antes y después de este tratamiento, en 45 pacientes estudiados, una clara mejoría del estado funcional de las grandes arterias de las extremidades inferiores. Los hallazgos obtenidos demuestran que los favorables resultados que se obtienen, se deben, por lo menos en parte, a la influencia sobre las alteraciones vasculares y no a la facilitación de la circulación colateral.