Endoscopy 2010; 42(1): 53-57
DOI: 10.1055/s-0029-1215377
Endoscopy essentials

© Georg Thieme Verlag KG Stuttgart · New York

Gastrointestinal bleeding: capsules, balloons, and spirals!

S.  S.  Rana1 , D.  K.  Bhasin1
  • 1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Further Information

Publication History

Publication Date:
11 January 2010 (online)

Gastrointestinal bleeding continues to be a challenging emergency for gastroenterologists despite the advances in modern medicine. Treatment of bleeding from gastric varices is a life-threatening emergency, and the lack of an ideal and universally acceptable method for arresting the bleed further complicates the situation. Over the years, small-bowel endoscopy has evolved from push enteroscopy to capsule endoscopy, balloon enteroscopy, and more recently to spiral enteroscopy. In addition, the concept and preliminary results of a therapeutic capsule endoscope are fascinating and it seems to be a technology of the future. Over time, the management of patients with bleeding peptic ulcers has radically changed from the administration of “tonnes” of antacids and emergency surgery to aggressive antisecretory therapy and various endoscopic injection, thermal, and mechanical hemostatic methods that reduce the need for emergency surgery. Now attempts are being made to identify the cost-effective dose of proton pump inhibitors (PPIs) that can be used following endoscopic therapy of bleeding peptic ulcers. Here, we review five studies published during the past year that reflect the state-of-the-art on the topic of gastrointestinal bleeding.

References

  • 1 Seewald S, Ang T L, Imazu H. et al . A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos).  Gastrointest Endosc. 2008;  68 447-454
  • 2 Chey W D, Elta G H. Natural history of gastric varices.  Gastroenterology. 1993;  105 599-602
  • 3 Tripathi D, Hayes P C. Endoscopic therapy for bleeding gastric varices: to clot or glue?.  Gastrointest Endosc. 2008;  68 883-886
  • 4 Kitamoto M, Imamura M, Kamada K. et al . Balloon-occluded retrograde transvenous obliteration of gastric varices with fundal hemorrhage.  AJR Am J Roentgenol. 2002;  178 1167-1174
  • 5 Lo G H, Liang H L, Chen W C. et al . A prospective, randomized controlled trail of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding.  Endoscopy. 2007;  39 679-685
  • 6 Procaccini N J, Al-Osaimi A MS, Northup P. et al . Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis.  Gastrointest Endosc. 2009;  70 881-887
  • 7 Akerman P A, Agrawal D, Cantero D, Pangtay J. Spiral enteroscopy with the new DSB overtube: a novel technique for deep peroral small-bowel intubation.  Endoscopy. 2008;  40 974-978
  • 8 Akerman P, Cantero D, Agrawal D. et al . Novel method of enteroscopy using EndoEase Discovery SB overtube.  Gastrointest Endosc. 2007;  65 AB125
  • 9 Cantero D, Akerman P A, Pangtay J. Retrograde spiral enteroscopy using the Fujinon EN-450T5 and Olympus SIF-180 200 cm enteroscopes with the Discovery SB Overtube.  Gastrointest Endosc. 2009;  69 AB192
  • 10 Buscaglia J M, Dunbar K B, Okolo 3rd  P I. et al . The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video).  Endoscopy. 2009;  41 194-199
  • 11 Akerman P A, Cantero D. Severe Complications of Spiral Enteroscopy in the First 1750 Patients.  Gastrointest Endosc. 2009;  69 AB127
  • 12 Schembre D, Ross A S. Yield of double balloon versus spiral enteroscopy for obscure gastrointestinal bleeding.  Gastrointest Endosc. 2009;  69 AB193
  • 13 Valdastri P, Quaglia C, Susilo E. et al . Wireless therapeutic endoscopic capsule: in vivo experiment.  Endoscopy. 2008;  40 979-982
  • 14 Rana S S, Bhasin D K. Gastrointestinal bleeding: from conventional to non conventional!.  Endoscopy. 2008;  40 40-44
  • 15 Travis A C, Wasan S K, Saltzman J R. Model to predict rebleeding following endoscopic therapy for non-variceal upper gastrointestinal hemorrhage.  J Gastroenterol Hepatol. 2008;  23 1505-1510
  • 16 Rollhauser C, Fleischer D E. Nonvariceal upper gastrointestinal bleeding.  Endoscopy. 2002;  34 111-118
  • 17 Saeed Z A, Winchester C B, Michaletz P A. et al . A scoring system to predict rebleeding after endoscopic therapy of nonvariceal upper gastrointestinal hemorrhage with a comparison of heat probe and ethanol injection.  Am J Gastroenterol. 1993;  88 1842-1849
  • 18 Camellini L, Merighi A, Pagnini C. et al . Comparison of three different risk-scoring systems in nonvariceal upper gastrointestinal bleeding.  Dig Liver Dis. 2004;  36 271-277
  • 19 Church N I, Dallal H J, Masson J. et al . Validity of the Rockall scoring system after endoscopic therapy for bleeding peptic ulcer: a prospective cohort study.  Gastrointest Endosc. 2006;  63 606-612
  • 20 Andriulli A, Loperfido S, Focareta R. et al . High- versus low-dose proton pump inhibitors after endoscopic hemostasis in patients with peptic ulcer bleeding: a multicentre, randomized study.  Am J Gastroenterol. 2008;  103 3011-3018
  • 21 Barkun A, Bardou M, Marshall J K. for the Nonvariceal Upper GI Bleeding Consensus Conference Group . Consensus recommendations for managing patients with Nonvariceal upper gastrointestinal bleeding.  Am Intern Med. 2003;  139 843-857
  • 22 Lau J YW, Sung J JY, Lee K KC. et al . Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.  N Engl J Med. 2000;  343 310-316
  • 23 Udd M, Miettinen P, Palmu A. et al . Regular-dose versus high-dose omeprazole in peptic ulcer bleeding: A prospective randomized double-blind study.  Scand J Gastroenterol. 2001;  36 1332-1338
  • 24 Schonekas H, Ahrens H, Pannewick U. et al . Comparison of two doses of intravenous pantoprazole in peptic ulcer bleeding.  Gastroenterology. 1999;  116 A305
  • 25 Javid G, Zargar S A, U-Saif R. et al . Comparison of p. o. or i. v. proton pump inhibitors on 72-h intragastric pH in bleeding peptic ulcer.  J Gastroenterol Hepatol. 2009;  24 1236-1243
  • 26 Choi K D, Kim N, Jang I J. et al . Optimal dose of intravenous pantoprazole in patients with peptic ulcer bleeding requiring endoscopic hemostasis in Korea.  J Gastroenterol Hepatol. 2009;  24 1617-1624

D. K. Bhasin

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER)

1041, Sector 24-B
Chandigarh 160 023
India

Fax: +91-172-2744401

Email: deepakkbhasin@gmail.com and dkbhasind@hotmail.com

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