Download PDF
Synfacts 2009(6): 0594-0594  
DOI: 10.1055/s-0029-1216671
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Blumiolide C

Contributor(s): Philip Kocienski, Arndt W. Schmidt
C. Hamel, E. V. Prusov, J. Gertsch, W. B. Schweizer, K.-H. Altmann*
ETH Zürich, Switzerland
Further Information

Publication History

Publication Date:
25 May 2009 (online)

    Permissions and Reprints

Significance

Blumiolide C was isolated from the soft coral Xenia blumi and exhibits promising anti-proliferative activity. Other Xenia diterpenoids have also shown anti-angiogenic or antibacterial properties. In contrast to the E-olefin moiety usually found in Xenia terpenoids, the double bond in the blumiolide C cyclononene is Z-configured.