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Synfacts 2009(7): 0745-0745  
DOI: 10.1055/s-0029-1217294
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

TunesPhos/1,2-Diamine-Ru(II) Complex Catalyzed Hydrogenation of Ketones

Contributor(s): Hisashi Yamamoto, Pingfan Li
W. Li, X. Sun, L. Zhou, G. Hou, S. Yu, X. Zhang*
Rutgers, The State University of New Jersey, Piscataway, USA and Northwest A&F University, Shaanxi, P. R. of China
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

TunePhos-type chiral diphosphine ligands have been demonstrated previously to be highly effective in the asymmetric hydrogenation of N-substituted allylphthalimides and α-keto ­esters. In this report, TunesPhos/1,2-diamine-­ruthenium(II) complexes catalyzed the asymmetric hydrogenation of various aromatic ketones with very high reactivity and excellent enantioselectivities.