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Synfacts 2009(7): 0797-0797  
DOI: 10.1055/s-0029-1217304
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Aziridination versus Addition Reaction

Contributor(s): Benjamin List, Frank Lay
T. Akiyama*, T. Suzuki, K. Mori
Gakushuin University, Tokyo, Japan
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

The authors report an aza-Darzens reaction of ethyl diazoacetate with a variety of PMP-protected aldimines catalyzed by chiral phosphoric acid 1. Aldimines are generated in situ from phenyl glyoxal derivatives and 4-anisidine. The three-component reaction yields cis-aziridines in excellent yields and high enantioselec­tivities.