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Synfacts 2009(8): 0886-0886
DOI: 10.1055/s-0029-1217439
DOI: 10.1055/s-0029-1217439
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
A Copper-Imidazoline-Aminophenol Complex for Asymmetric 1,4-Additions
N. Yokoyama, T. Arai*
Chiba University, Japan
Further Information
Publication History
Publication Date:
23 July 2009 (online)
Significance
A new nitro-substituted imidazoline-aminophenol-copper complex is shown to be a powerful and general Lewis acid for the 1,4-addition reaction of pyrroles and indoles with nitro-alkenes. The resulting adducts can undergo NO2 reduction followed by Pictet-Spengler cyclization in good yields and diastereoselectivities.