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Synfacts 2009(8): 0876-0876  
DOI: 10.1055/s-0029-1217442
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Nucleophilic Substitution of Bromocyclopropanes

Contributor(s): Mark Lautens, Jacki Kitching
B. K. Alnasleh, W. M. Sherrill, M. Rubina, J. Banning, M. Rubin*
The University of Kansas, Lawrence, USA
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

Further to previous research concerning 1,2-dehydrohalogenations of bromo­cyclopropanes (Tetrahedron 2008, 64, 8610; Synthesis 2009, 1477), the authors now provide a diastereoselective procedure for the inter- and ­intramolecular formal substitution of bromocyclopropanes with oxygen- and nitrogen-based nucleophiles.