A New and Simple Synthesis
of Sulfonyl Ureas from Sulfonamides and N-Alkyl-1,2,4-dithiazolidine-3,5-diones

Richard K. Gessner; Kelly Chibale

doi:10.1055/s-0029-1217960

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Synlett 2009(17): 2839-2843
DOI: 10.1055/s-0029-1217960

LETTER

A New and Simple Synthesis of Sulfonyl Ureas from Sulfonamides and N-Alkyl-1,2,4-dithiazolidine-3,5-diones

Richard K. Gessner^a, Kelly Chibale*^a,b
^a Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
Fax: +27(21)6897499; e-Mail: Kelly.Chibale@uct.ac.za;
^b Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

Further Information

Publication History

Received 17 July 2009
Publication Date:
09 September 2009 (online)

Abstract
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Abstract

A new, short, and simple synthetic approach to sulfonyl ureas is reported. The method involves the transformation of readily synthesized N-alkyl-1,2,4-dithiazolidine-3,5-diones by reaction with primary sulfonamides. Sulfonyl ureas were obtained in moderate to high yields.

Key words

sulfonyl ureas - isocyanates - sulfonamides - heterocycles - protecting group

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