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Synfacts 2009(11): 1289-1289  
DOI: 10.1055/s-0029-1218073
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Henry Reaction with Nano-NAP

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
H. Hagiwara*, M. Sekifuji, N. Tsubokawa, T. Hoshi, T. Suzuki
Niigata University, Japan
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

Aminopropylated nanosilica particles (nano-NAP) catalyzed the Henry reaction of arene carboaldehydes 1 with nitroalkanes 2 (R² = H, Me) to give the corresponding nitrostyrenes 3 in 44-95% yield (8 examples). The catalyst was recovered by centrifugation and reused twice for the formation of 3a (1st reuse: 12 h, 81%; 2nd reuse: 16 h, 52%).