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Synfacts 2010(1): 0017-0017  
DOI: 10.1055/s-0029-1218394
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Kendomycin

Contributor(s): Philip Kocienski
T. Magauer, H. J. Martin, J. Mulzer*
University of Vienna, Austria
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

Kendomycin is a potent endothelin receptor antagonist and antiosteoporotic compound. It is also an antibiotic and cytostatic agent. The challenging macrocyclization to form the ansa ring was accomplished by a photo-Fries rearrangement (H → I).