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Synfacts 2010(1): 0095-0095  
DOI: 10.1055/s-0029-1218438
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

CuX2-Mediated [4+2] Benzannulation for the Synthesis of Haloaromatic Compounds

Contributor(s): Paul Knochel, Tobias Thaler
Y. Isogai, Menggenbateer, F. N. Khan, N. Asao*
Tohoku University, Sendai, Japan
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

A novel benzannulation-based method for the synthesis of halogenated aromatic compounds has been developed. CuCl2 does not only act as a Lewis acid in the benzannulation step, but also plays the role of a halogenating agent.