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Synfacts 2010(1): 0113-0113  
DOI: 10.1055/s-0029-1218450
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Mukaiyama Aldol Reaction with Sc(III)-USY

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
A. Olmos, A. Alix, J. Sommer*, P. Pale*
Institut de Chimie de Strasbourg, France
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Publication History

Publication Date:
21 December 2009 (online)

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Significance

Sc(III)-doped USY zeolite [Sc(III)-USY] was prepared by the treatment of H-USY with Sc(OTf)3 under N2 stream at 450 ˚C for two days. Sc(III)-USY (1 or 10 mol% Sc) catalyzed the Mukaiyama aldol reaction of silyl enol ethers 1 with aldehydes 2 at room temperature to give the corresponding aldol adducts 3 in up to 100% yield (20 examples).