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Synthesis 2010(10): 1741-1744
DOI: 10.1055/s-0029-1218692
DOI: 10.1055/s-0029-1218692
PSP
© Georg Thieme Verlag
Stuttgart ˙ New York
Practical One-Pot Syntheses of Regioisomeric Furan-Fused Pyridinones (and Quinolinones) from Common Precursors
Further Information
Received
15 January 2010
Publication Date:
09 March 2010 (online)
Publication History
Publication Date:
09 March 2010 (online)
Abstract
3-Alkynyl-4-methoxypyridin-2(1H)-ones undergo cyclization via divergent pathways when heated in acetic acid or triethylamine as reagent-solvent under microwave irradiation to furnish selectively furo[2,3-b]pyridin-4-ones or their regioisomeric furo[3,2-c]pyridin-4-ones, respectively. The same strategy applies to the synthesis of furoquinolinones.
Key words
annulation - furan - alkyne - cross-coupling reaction - microwave irradiation
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