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Synthesis 2010(15): 2512-2514  
DOI: 10.1055/s-0029-1218823
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Short and Efficient Synthesis of (S)-(+)-2-(Hydroxymethyl)-6-piperidin-2-one

Puspesh K. Upadhyay, Pradeep Kumar*
Division of Organic Chemistry, National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)25902629; e-Mail: pk.tripathi@ncl.res.in;
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Publication History

Received 1 April 2010
Publication Date:
18 June 2010 (online)

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Abstract

A concise synthesis of (S)-(+)-2-(hydroxymethyl)-6-piperidin-2-one is described that employs l-aspartic acid as chiral pool starting material and Wittig reaction as the key step.

Key words

Wittig reaction - amino acid - piperidone - l-aspartic acid­ - hydrogenation - pipecolate

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