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Planta Med 2000; 66(1): 84-86
DOI: 10.1055/s-0029-1243118
Letter

© Georg Thieme Verlag Stuttgart · New York

Antinociceptive Activity of I3,II8-Binaringenin, a Biflavonoid Present in Plants of the Guttiferae

Magali Bittar1 , Márcia Maria de Souza1 , Rosendo A. Yunes2 , Rossana Lento3 , Franco Delle Monache3 , Valdir Cechinel Filho1 ,*
  • 1Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil
  • 2Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil
  • 3Centro Chimica Recettori, CNR, Rome, Italy
Further Information

Publication History

Received: April 27, 1999

Accepted: June 3, 1999

Publication Date:
24 November 2009 (online)

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Abstract

This paper describes the antinociceptive action of I3,II8-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, in a writhing test and a formalin test. It was found that it exhibits potent and dose-related antinociceptive action in both experimental models, with ID50 values of 22µmol/kg against the writhing test and 28µmol/kg against the second phase of the formalin test. It was more potent than some well-known analgesic drugs used as reference. Based on a hot- plate test its mechanism of action seems to be unrelated with the opioid receptors.

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Valdir Cechinel Filho

Núcleo de Investigações

Químico-Farmacêuticas (NIQFAR)/CCS

Universidade do Vale do Itajaí (UNIVALI)

88302-202, Itajaí, SC

Brazil

Email: cechinel@mbox1.univali.rct-sc.br

Fax: +55-47-3417601

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