Activity of Solidagenone and their Semisynthetic Derivatives on the Glucocorticoid-Mediated Signal Transduction

Abstract

The labdane diterpene solidagenone and four semisynthetic derivatives were assessed for effects on the glucocorticoid-mediated signal transduction. Solidagenone and the derivatives proved to be active with IC₅₀ values between 1 and 25 µg/mL. All compounds were cytotoxic towards L 1210, BHK and COS 7 cells with IC₅₀ from 10–100 µg/mL.

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